NDLI: Temperaturerhöhung unter Oxybutynin bei Patienten mit Spina bifida.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cremer, R.
Description	Author Affiliation: Cremer R ( Spina bifida Ambulanz, Kliniken der Stadt Köln gGmbH, Kinderkrankenhaus, Amsterdamer Straße 59, 50735 Köln, Deutschland. CremerR@kliniken-koeln.de)
Abstract	Paraplegic spina bifida patients often suffer from disturbed sweat secretion in the paretic regions. A diminished sweat production of caudal parts of the body is compensated by an increased secretion of sweat in parts cranial to the lesion to maintain temperature homoeostais. If the sweat secretion is blocked by anticholinergic effects of urotherapeutic drugs (for instance oxybutynin) hyperthermia can result as a side effect as these casuistic examples show.An 8-year-old girl with a lumbar meningomyelocele and a neurogenic bladder reported a dry skin and hyperthermia up to 38,5°C during oral therapy with oxybutynin (0.4 mg per kg body weight) during hot summer days. Similar symptoms were shown by a 7-year-old male patient with a sacral meningomyelocele and neurogenic bladder on oral therapy of 0.35 mg oxybutynin per kg body weight. A 4-year-old female patient with lumbar spina bifida and neurogenic bladder reacted to intravesical administration of 0.4 and 0.3 mg per kg body weight during early summertime with hyperthermia up to 38°C. In this case the medication had been started in wintertime and was primarily well tolerated.Hyperthermia under treatment with anticholinergic drugs has mainly been published for geriatric patients with sometimes fatal outcome. In the pediatric literature there is only one warning regarding the use of oxybutynin in children with spina bifida living in high temperature regions. It is remarkable that hyperthermia can also happen after intravesical administration of oxybutynin in usual dosage.
File Format	HTM / HTML
ISSN	03402592
Issue Number	7
Volume Number	51
e-ISSN	14330563
Journal	Der Urologe
Language	German
Publisher	Springer
Publisher Date	2012-07-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Urology Fever Drug Therapy Etiology Mandelic Acids Therapeutic Use Spinal Dysraphism Complications Child Female Diagnosis Humans Male Parasympatholytics Pharmacokinetics Treatment Outcome Case Reports English Abstract Journal Article
Alternative Title	Hyperthermia in spina bifida patients treated with oxybutynin
Content Type	Text
Resource Type	Case study Article
Subject	Urology

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