NDLI: Patienten mit Prostatakrebs nach radikaler Prostatektomie : Stadienmigration und Veränderung von Tumoreigenschaften in den Jahren 1998-2012.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Walther, A. Kron, M. Klorek, T. Gschwend, J. E. Herkommer, K.
Description	Author Affiliation: Walther A ( Urologische Klinik, Klinikum rechts der Isar der TU München, Ismaningerstraße 22, 81675, München, Deutschland.); Kron M ( Institut für Epidemiologie und Medizinische Biometrie, Universität Ulm, Ulm, Deutschland.); Klorek T ( Urologische Klinik, Klinikum rechts der Isar der TU München, Ismaningerstraße 22, 81675, München, Deutschland.); Gschwend JE ( Urologische Klinik, Klinikum rechts der Isar der TU München, Ismaningerstraße 22, 81675, München, Deutschland.); Herkommer K ( Urologische Klinik, Klinikum rechts der Isar der TU München, Ismaningerstraße 22, 81675, München, Deutschland. kathleen.herkommer@tum.de.)
Abstract	BACKGROUND: The aim of this study was to verify the described inverse stage migration after radical prostatectomy by a tertiary care center in 2011 in a national collective. MATERIALS AND METHODS: Data from 10,323 patients with prostate cancer (PCa), who had radical prostatectomy between 1998 and 2012, were analyzed regarding prostate-specific antigen (PSA) and age at diagnosis, T stage, and Gleason score. A trend over time was determined by using the Jonckheere-Terpstra test. RESULTS: Median age at surgery was 65 years (1998: 63.7; 2012: 66.5). The proportion of low-risk tumors decreased from 39% in 2005 to 25% in 2012, while the intermediate-risk tumors showed a continuous increase since 1998 from 35 to 52% in 2012. The proportion of patients with a Gleason score ≤ 6 decreased from 60% in 1998 to 25 % in 2012. The Gleason score groups 7a and 7b, however, increased from 12 to 46, % and 12 to 19%, respectively. The proportion of tumors with a Gleason score of 8-10 decreased from 16 to 10%. The proportion of organ-confined prostate cancer increased from 1998 to 2007 continuously from 57 to 73%. Since 2007 the proportion dropped to 64%. CONCLUSIONS: In this national population a trend towards inverse stage migration can be noted. Both the increase in Gleason score ≥ 6 and intermediate-risk tumors can be explained by the modification of the Gleason score. The tendency towards higher age and nonorgan-confined cancers at surgery could be dependent of the growing recognition of radical prostatectomy as a treatment for locally advanced prostate cancer, on the one hand, and the increase of alternative treatments for low-risk cancers, on the other hand.
File Format	HTM / HTML
ISSN	03402592
Issue Number	2
Journal	Der Urologe
Volume Number	55
e-ISSN	14330563
Language	German
Publisher	Springer
Publisher Date	2016-02-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Urology
Alternative Title	Patients with prostate cancer after radical prostatectomy: Stage migration and changes in tumor characteristics from 1998-2012
Content Type	Text
Resource Type	Article
Subject	Urology

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