NDLI: Molekulare Diagnostik der blasenbildenden Autoimmundermatosen.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hoffmann, K. Hertl, M. Sitaru, C.
Description	Author Affiliation: Hoffmann K ( Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstraße 7, 79104, Freiburg, Deutschland.); Hertl M ( Klinik für Dermatologie und Allergologie, Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg, Deutschland.); Sitaru C ( Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstraße 7, 79104, Freiburg, Deutschland. cassian@mail.sitaru.eu.)
Abstract	Bullous autoimmune diseases are organ-specific disorders characterized by an autoantibody-mediated blistering of skin and mucous membranes. The detection of tissue-bound and serum autoantibodies is prerequisite for the diagnosis of autoimmune blistering diseases. The individual entities of this group may be difficult to differentiate on clinical grounds alone. An accurate diagnosis is however important for prognosis and therapy. A preliminary diagnostic step includes direct and indirect immunofluorescence microscopy, which provide information about the binding pattern and isotype of autoantibodies and allow the diagnosis of the autoimmune blistering disease. Subsequent characterization of the molecular specificity of autoantibodies is necessary for the exact classification of autoimmune bullous dermatoses. The quantitative measurement of autoantibodies against structural proteins of the skin may be often used to assess disease severity at follow-up.
File Format	HTM / HTML
ISSN	00178470
Issue Number	1
Volume Number	67
e-ISSN	14321173
Journal	Der Hautarzt
Language	German
Publisher	Springer
Publisher Date	2016-01-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine Discipline Dermatology Autoimmune Diseases Diagnosis Immunology Immunoassay Methods Molecular Diagnostic Techniques Skin Diseases Autoantibodies Humans Journal Article Review
Alternative Title	Molecular diagnosis of autoimmune dermatoses
Content Type	Text
Resource Type	Article
Subject	Dermatology

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