NDLI: Acute inhibitory effects of clenbuterol on force, $Ca^{2+}$ transients and action potentials in rat soleus may not involve the $β_{2}-adrenoceptor$ pathway

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Acute inhibitory effects of clenbuterol on force, $Ca^{2+}$ transients and action potentials in rat soleus may not involve the $β_{2}-adrenoceptor$ pathway

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Acute inhibitory effects of clenbuterol on force, $Ca^{2+}$ transients and action potentials in rat soleus may not involve the $β_{2}-adrenoceptor$ pathway

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Head, Stewart I. Ha, Tuyen N. V.
Description	Country affiliation: Australia Author Affiliation: Head SI ( School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.)
Abstract	1. Clenbuterol, a ß(2)-adrenoceptor agonist, can have inhibitory and myotoxic effects on slow-twitch muscles. Clenbuterol is lipophilic and may enter into the intracellular compartment, and because of this, it is likely that clenbuterol will have different effects to classical ß(2)-adrenoceptor agonists such as terbutaline. The aim of the present study is to investigate clenbuterol's effect on force, intracellular [Ca(2+)] and electrophysiology, and the role of the ß(2)-adrenoceptor pathway in these effects. 2. Simultaneous measurements of isometric force and [Ca(2+)](i) were made from small bundles of rat soleus muscle fibres in which several superficial fibres had been pressure-injected with the fluorescence Ca(2+) indicator Indo-1. The muscle's electrophysiological response was measured using glass intracellular microelectrodes. 3. The most robust effect of clenbuterol was a concentration- (10-50 µmol/L) and frequency-dependent (10-80 Hz) loss of force and [Ca(2+)](i) maintenance during tetanic stimulation of muscle fibres. None of these effects were reduced in the presence of the ß(2)-antagonist ICI 118551. 4. In addition clenbuterol had a significant effect on muscle electrophysiology, with action potentials measured during tetanic trains being inhibited in a concentration- and frequency-dependent manner. This response was also unchanged by pre-treatment with the ß(2)-antagonist ICI 118551. 5. These results indicate that some of clenbuterol's effects are mediated through a pathway other than the ß(2)-adrenoceptors.
File Format	HTM / HTML
ISSN	03051870
Issue Number	9
Volume Number	38
e-ISSN	14401681
Journal	Clinical and Experimental Pharmacology and Physiology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-09-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Pharmacology Adrenergic Beta-agonists Pharmacology Calcium Metabolism Clenbuterol Muscle Fibers, Skeletal Drug Effects Receptors, Adrenergic, Beta-2 Action Potentials Adrenergic Beta-2 Receptor Antagonists Animals Indoles Male Muscle Contraction Physiology Muscle Strength Potassium Propanolamines Rats Rats, Wistar Journal Article
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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