NDLI: Effects of magnolol on vascular contraction in rat aortic rings.

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Effects of magnolol on vascular contraction in rat aortic rings.

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Effects of magnolol on vascular contraction in rat aortic rings.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seok, Young Mi Kim, Hye Young Garmaa, Otgonbayar Cha, Byung-Yoon Woo, Je-Tae Kim, In Kyeom
Description	Author Affiliation: Seok YM ( Cardiovascular Research Institute, Kyungpook National University School of Medicine, Daegu, Korea.)
Abstract	1. Magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) is a major phenolic compound purified from Magnolia officinalis. The aim of the present study was to elucidate the effects of magnolol on vascular contractions. 2. Rat aortic rings were mounted in organ baths. Magnolol was added cumulatively (0.3-30 µmol/L) to elicit relaxation in endothelium-intact and -denuded rat aortic rings precontracted with U46619 (30 nmol/L, 20 min), NaF (8.0 mmol/L, 40 min), phenylephrine (1.0 or 0.1 µmol/L, 15 min) or phorbol-12,13-dibutyrate (PDBu, 0.3 or 0.1 µmol/L, 40 min). In separate experiments, cumulative concentrationresponse curves were obtained for NaF (2.0-12 mmol/L), U46619 (1.0 nmol/L1.0 µmol/L) or PDBu (1.0 nmol/L1.0 µmol/L) after pretreatment with either magnolol or vehicle for 30 min in endothelium-denuded aortic rings. After completion of the functional study, we measured the amount of guanosine triphosphate (GTP) RhoA by using a G-LISA RhoA Activation Assay, as well as the phosphorylation of 20 kDa myosin light chain (MLC20), myosin phosphatase-targeting subunit 1 (MYPT1) and protein kinase C-potentiated inhibitory protein for heterotrimeric myosin light-chain phosphatase of 17 kDa (CPI-17) by immunobloting. 3. Magnolol (0.3-30 µmol/L) reduced vascular tension induced by the thromboxane A2 agonist U46619 (30 nmol/L), sodium fluoride (NaF) (8.0 mmol/L) and the 1 -adrenoceptor agonist phenylephrine (1.0 or 0.1 µmol/L) in both endothelium-intact and -denuded rings. The magnitude of the relaxation effects of magnolol on the contraction induced by each of the drugs were similar. The magnitude of the effect of magnolol in endothelium-intact and -denuded rings were similar. 4. Pretreatment of rat aortic rings with 1.0, 3.0 or 10 µmol/L magnolol for 30 min dose-dependently inhibited the maximum response on the concentration-response curves to NaF and U46619, but not to phorbol-12,13-dibutyrate (PDBu). 5. Magnolol (3.0 or 10 µmol/L) decreased RhoA activation, as well as the phosphorylation of MLC20 , MYPT1(Thr855) and CPI-17(Thr38) induced by either 8.0 mmol/L NaF or 30 nmol/L U46619. In contrast, magnolol did not affect PDBu (0.1 µmol/L)-induced phosphorylation of CPI-17(Thr38) . 6. In conclusion, magnolol reduces vascular contraction by inhibiting the RhoA/Rho kinase pathway in endothelium-denuded rat aorta.
File Format	HTM / HTML
ISSN	03051870
Issue Number	1
Volume Number	39
e-ISSN	14401681
Journal	Clinical and Experimental Pharmacology and Physiology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-01-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Pharmacology Aorta, Thoracic Drug Effects Biphenyl Compounds Pharmacology Lignans Signal Transduction Vasodilation Vasodilator Agents Rho-associated Kinases Metabolism Rhoa Gtp-binding Protein Animals In Vitro Techniques Male Molecular Weight Muscle Proteins Chemistry Muscle, Smooth, Vascular Myosin Light Chains Osmolar Concentration Phosphoproteins Phosphorylation Protein Phosphatase 1 Protein Processing, Post-translational Rats Rats, Sprague-dawley Vasoconstrictor Agents Antagonists & Inhibitors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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