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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huang, Rae-Chi Mori, Trevor A. Beilin, Lawrence J. |
| Spatial Coverage | Australia |
| Description | Country affiliation: Australia Author Affiliation: Huang RC ( School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia) |
| Abstract | The Raine study (http://www.rainestudy.org.au, accessed 18 June 2012) is a longitudinal Australian birth cohort that has serially assessed the offspring of 2900 pregnant women from 18 weeks gestation in utero to 17 years of age. The Raine study data have shown that low birth weight is a surrogate for poor in utero growth from 18 weeks gestation. A U-shaped relationship between birth size and cardiometabolic risk exists in this Western Australian cohort, implying that both low and high birth weight are associated with increased risk. High birth weight is a risk factor for cardiometabolic risk, particularly for females. Lifetime adiposity trajectories are better at predicting metabolic risk of the offspring than birth size or current body mass index. Therefore, early life programming is an ongoing process, starting in utero and undergoing at least some level of modification in parallel with changes in adiposity during early childhood. Maternal smoking during pregnancy, maternal obesity, hypertension and diabetes increase the risk for metabolic risk in the offspring. Breast feeding is protective for cardiometabolic risk in this Australian cohort. |
| File Format | HTM / HTML |
| ISSN | 03051870 |
| Issue Number | 11 |
| Volume Number | 39 |
| e-ISSN | 14401681 |
| Journal | Clinical and Experimental Pharmacology and Physiology |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-11-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology Discipline Pharmacology Birth Weight Physiology Cardiovascular Diseases Physiopathology Metabolic Diseases Animals Australia Etiology Cohort Studies Female Humans Longitudinal Studies Pregnancy Risk Factors Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Pharmacology |
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