NDLI: Coadministration of ß-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: a different mechanism from Madopar.

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Coadministration of ß-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: a different mechanism from Madopar.

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Coadministration of ß-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: a different mechanism from Madopar.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, Liping Deng, Minzhen Zhang, Sheng Fang, Yongqi Li, Ling
Description	Country affiliation: China Author Affiliation: Huang L ( The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.)
Abstract	The aim of the present study was to investigate the effect of coadministration of ß-asarone and levodopa (l-dopa) on increasing dopamine (DA) in the striatum of healthy rats. Rats were randomly divided into four groups: (i) a normal group, administered normal saline; (ii) a Madopar group, administered 75 mg/kg Madopar (l-dopa : benserazide, 4 : 1); (iii) an l-dopa group, administered 60 mg/kg l-dopa; and (iv) a group coadministered 15 mg/kg ß-asarone and 60 mg/kg l-dopa. All drugs (or normal saline) were administered intragastrically twice a day for 7 days. Then, plasma and striatum concentrations of DA, l-dopa, 5-hydroxytryptamine (5-HT), homovanillic acid (HVA), 3,4-dihydroxyphenylacetic acid (DOPAC), tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAO-B) were determined. In the group coadministered ß-asarone and l-dopa, there was a decline in plasma and striatal concentrations of l-dopa; however, DA and DOPAC concentrations increased in the striatum and plasma and plasma HVA concentrations increased, whereas there was no significant change in striatal levels. Concentrations of 5-HT in the striatum and plasma were similar in the coadministered and Madopar-treated groups. In addition, plasma and striatal COMT levels decreased after coadministration of ß-asarone and l-dopa, whereas there were no significant differences in MAO-B concentrations among groups. Furthermore, coadministration of ß-asarone and l-dopa increased plasma TH concentrations. Altogether, ß-asarone affects the conversion of l-dopa to DA by modulating COMT activity and DA metabolism. The mechanism of coadministration is different from that of Madopar in Parkinson's disease (PD) treatment. Thus, the coadministration of ß-asarone and l-dopa may be beneficial in the treatment of PD.
File Format	HTM / HTML
ISSN	03051870
Issue Number	9
Volume Number	41
e-ISSN	14401681
Journal	Clinical and Experimental Pharmacology and Physiology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-09-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Pharmacology Anisoles Pharmacology Benserazide Corpus Striatum Drug Effects Metabolism Dopamine Levodopa 3,4-dihydroxyphenylacetic Acid Blood Animals Administration & Dosage Catechol O-methyltransferase Dopamine Agents Drug Combinations Drug Interactions Homovanillic Acid Male Monoamine Oxidase Rats Serotonin Tyrosine 3-monooxygenase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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