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Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moniuszko, Marcin Bodzenta-Lukaszyk, Anna Kowal, Krzysztof Lenczewska, Danuta Dabrowska, Milena
Description	Country affiliation: Poland Author Affiliation: Moniuszko M ( Department of Allergology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie Street 24A, 15-276 Bialystok, Poland. moniuszm@umwb.edu.pl)
Abstract	CD16+ monocytes are expanded in various inflammatory conditions. Recently it was reported that CD16+ monocytes can be divided into two subsets with contrasting potential of modulating inflammatory responses, namely CD14++CD16+ and CD14+CD16+ monocytes. Here, we characterized and quantified CD14++CD16+ and CD14+CD16+ monocyte subsets in asthmatic patients in the context of severity of disease and different treatment options. Subjects included seventeen severe asthmatics and eighteen moderate asthmatics treated with moderate-to-high doses of inhaled glucocorticosteroids (GCS), twenty nine steroid-naive mild asthmatics and fifteen healthy controls. First, we demonstrated that CD14++CD16+ monocytes, in contrast to CD14+CD16+ monocytes, present significantly higher expression of anti-inflammatory molecule CD163. The frequency of CD14++CD16+, but not CD14+CD16+ monocytes, was significantly higher in patients with severe asthma as compared to mild and moderate asthmatics. However, the frequency of both CD16+ monocyte subsets did not correlate directly with exhaled nitric oxide levels. Short-term administration of oral GCS in patients with exacerbations resulted in a preferential decrease of CD14+CD16+ monocytes. Our study indicates that CD14++CD16+ and CD14+CD16+ monocyte subsets in asthmatics are differentially modulated by both the inflammatory process and GCS treatment.
File Format	HTM / HTML
ISSN	15216616
Issue Number	3
Volume Number	130
e-ISSN	15217035
Journal	Clinical Immunology
Language	English
Publisher	Elsevier
Publisher Date	2009-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Antigens, Cd14 Immunology Asthma Leukocytes, Mononuclear Receptors, Igg Adult Antigens, Cd Metabolism Antigens, Differentiation, Myelomonocytic Female Flow Cytometry Gene Expression Regulation Drug Effects Glucocorticoids Pharmacology Humans Immunohistochemistry Male Methylprednisolone Middle Aged Nitric Oxide Analysis Receptors, Cell Surface Severity Of Illness Index Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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