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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhou, Ying Yuan, Jun Pan, Yujun Fei, Yiping Qiu, Xiangning Hu, Nan Luo, Yongqi Lei, Wenzhi Li, Yaping Long, Hai Sawalha, Amr H. Richardson, Bruce Lu, Qianjin |
| Description | Author Affiliation: Zhou Y ( Department of Dermatology and Epigenetic Research Center, Second Xiangya Hospital, Central South University, 139 Renmin Middle Rd, Changsha, Hunan 410011, PR China.) |
| Abstract | CD40 ligand (CD40LG), encoded on the X chromosome, has been reported to be overexpressed on lupus T cells. Herein, we investigated the effect of DNA demethylation on T cell CD40LG expression and the production of IgG by autologous B cells in lupus. We found normal human T cells transfected with CD40LG induced autologous B cell activation and plasma cell differentiation. Both female lupus CD4+ T cells and demethylating agents treated CD4+ T cells overexpressed CD40LG mRNA. Further, lupus T cells from both genders or demethylated CD4+ T cells from healthy women overstimulated autologous B cells, and this could be reversed with anti-CD40LG Ab in only females. We demonstrated that female lupus CD4+ T cells and demethylated CD4+ T cells express high level of CD40LG and overstimulate B cells to produce IgG. This is due to DNA demethylation and thereby reactivation of the inactive X chromosome in female. |
| File Format | HTM / HTML |
| ISSN | 15216616 |
| e-ISSN | 15217035 |
| DOI | 10.1016/j.clim.2009.05.011 |
| Journal | Clinical Immunology |
| Issue Number | 3 |
| Volume Number | 132 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Antibody Formation Immunology B-lymphocytes Cd40 Ligand Genetics Gene Expression Regulation Immunoglobulin G Lupus Erythematosus, Systemic T-lymphocytes Metabolism Adolescent Antibodies, Monoclonal Pharmacology Drug Effects Antigens, Cd Cd4-positive T-lymphocytes Cd8-positive T-lymphocytes Dna Methylation Enzyme Inhibitors Lipopolysaccharides Lymphocyte Activation Sex Characteristics Transfection Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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