NDLI: Dendritic cells in atherosclerotic disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Niessner, Alexander Weyand, Cornelia M.
Description	Country affiliation: Austria Author Affiliation: Niessner A ( Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. alexander.niessner@meduniwien.ac.at)
Abstract	Atherosclerosis has been considered a syndrome of dysregulated lipid storage until recent evidence has emphasized the critical contribution of the immune system. Dendritic cells (DC) are positioned at the interface of the innate and adaptive immune system. Recognition of danger signals in atheromas leads to DC activation. Activated DC regulate effector T cells which can kill plaque-resident cells and damage the plaque structure. Two types of DC have been identified in atherosclerotic lesions; classical myeloid DC (mDC) which mainly recognize bacterial signatures and plasmacytoid DC (pDC) which specialize in sensing viral fragments and have the unique potential of producing large amounts of type I interferon (IFN). In human atheromas, type I IFN upregulates expression of the cytotoxic molecule TRAIL which leads to apoptosis of plaque-resident cells. This review will elucidate the role of DC in atherogenesis and particularly in plaque rupture, the underlying pathophysiologic cause of myocardial infarction.
File Format	HTM / HTML
ISSN	15216616
e-ISSN	15217035
DOI	10.1016/j.clim.2009.05.006
Journal	Clinical Immunology
Issue Number	1
Volume Number	134
Language	English
Publisher	Elsevier
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Adaptive Immunity Immunology Atherosclerosis Dendritic Cells Immunity, Innate Animals Metabolism Pathology Cytotoxicity, Immunologic Cytology Interferon Type I Models, Immunological T-lymphocytes Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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