NDLI: Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome.

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Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Szabo, Krisztina Papp, Gabor Barath, Sandor Gyimesi, Edit Szanto, Antonia Zeher, Margit
Description	Author Affiliation: Szabo K ( Division of Clinical Immunology Institute of Medicine, Medical and Health Science Center University of Debrecen Debrecen Hungary. krsztn.szabo@gmai.hu)
Abstract	The aim of this study was to investigate the possible role of follicular helper T (TFH) cells in the pathogenesis of primary Sjögren's syndrome (pSS) by analyzing immune-competent cells and serological markers with special emphasis on clinical symptoms. We enrolled 50 pSS patients and 16 healthy individuals in the study. Patients had elevated ratio of peripheral TFH cells, however, when dividing patients into two groups defined by the presence of extraglandular manifestations (EGMs), only patients with EGMs differed from controls significantly. Moreover, TFH cell percentages correlated positively with both activated T cell and Tr1 cell values. On the contrary, TFH cell percentages showed negative correlation with both IgM and IgG memory B cell proportions. Elevated TFH percent ages were observed in the anti-SSA/SSB positive patients, and also in patients with higher IL-12, IL-21 levels and focus score values. Increased TFH cell proportions seem to have an important role in disease development.
File Format	HTM / HTML
ISSN	15216616
Issue Number	2
Volume Number	147
e-ISSN	15217035
Journal	Clinical Immunology
Language	English
Publisher	Elsevier
Publisher Date	2013-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Sjogren's Syndrome Immunology T-lymphocytes, Helper-inducer Aged Autoantibodies Autoantigens Case-control Studies Cytokines Blood Female Humans Male Middle Aged Ribonucleoproteins Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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