NDLI: Diagnostic value of tolerance-related gene expression measured in the recipient alloantigen-reactive T cell fraction.

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Diagnostic value of tolerance-related gene expression measured in the recipient alloantigen-reactive T cell fraction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lim, Dong-Gyun Park, Youn-Hee Kim, Sung-Eun Jeong, Seong-Hee Kim, Song-Cheol
Description	Author Affiliation: Lim DG ( Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.)
Abstract	The efficient development of tolerance-inducing therapies and safe reduction of immunosuppression should be supported by early diagnosis and prediction of tolerance in transplantation. Using mouse models of donor-specific tolerance to allogeneic skin and islet grafts we tested whether measurement of tolerance-related gene expression in their alloantigen-reactive peripheral T cell fraction efficiently reflected the tolerance status of recipients. We found that Foxp3, Nrn1, and Klrg1 were preferentially expressed in conditions of tolerance compared with rejection or unmanipulated controls if their expression is measured in CD69(+) T cells prepared from coculture of recipient peripheral T cells and donor antigen-presenting cells. The same pattern of gene expression was observed in recipients grafted with either skin or islets, recipients of different genetic origins, and even those taking immunosuppressive drugs. These findings suggest that the expression of tolerance-related genes in the alloantigen-reactive T cell fraction could be used to detect tolerance in the clinic.
File Format	HTM / HTML
ISSN	15216616
Issue Number	2
Volume Number	148
e-ISSN	15217035
Journal	Clinical Immunology
Language	English
Publisher	Elsevier
Publisher Date	2013-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Gene Expression Regulation Immunology Immune Tolerance Physiology Isoantigens T-lymphocytes Metabolism Animals Coculture Techniques Cyclosporine Pharmacology Immunosuppressive Agents Islets Of Langerhans Transplantation Mice Mice, Inbred Strains Sirolimus Skin Transplantation Specific Pathogen-free Organisms Spleen Cytology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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