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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Collins, Erin Gilkeson, Gary |
| Description | Country affiliation: United States Author Affiliation: Collins E ( Division of Rheumatology, Medical University of South Carolina and the Medical Research Service of the Ralph H. Johnson VAMC, Charleston, SC, USA.) |
| Abstract | Cell based therapies are of increasing interest in the treatment of systemic lupus due to their potential for long term suppression or cure of disease. Two methods for stem cell transplantation are currently being investigated/performed for treatment of lupus. Autologous hematopoetic stem cell transplantation is used in patients refractory to standard therapy. The morbidity and mortality of the procedure limit its use to select patients. Results indicate 50% long term disease free survival. The technical difficulty of the procedure requires it to be performed only in experienced centers. Mesenchymal stem cell transplants are a new emerging therapy for the treatment of lupus. Studies in murine models of lupus provide evidence of efficacy with safety. Limited uncontrolled trials in humans provide evidence of efficacy as well. Controlled trials are needed to assess the efficacy of both these therapies compared to standard therapy. |
| File Format | HTM / HTML |
| ISSN | 15216616 |
| Issue Number | 3 |
| Volume Number | 148 |
| e-ISSN | 15217035 |
| Journal | Clinical Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Hematopoietic Stem Cell Transplantation Lupus Erythematosus, Systemic Therapy Mesenchymal Stem Cell Transplantation Animals Humans Immunology Mortality Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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