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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jang, Young-Soon Kang, Wonseok Chang, Dong-Yeop Sung, Pil Soo Park, Bum-Chan Yoo, Seok Ho Park, Young Woo Shin, Eui-Cheol |
| Description | Author Affiliation: Jang YS ( Department of Biological Sciences, KAIST, Daejeon 305-701, Republic of Korea) |
| Abstract | We investigated regulation of human NK cell function by CD27 engagement using a recombinant soluble CD70 protein. CD27 was preferentially expressed on CD56(bright) NK cells, and soluble CD70 protein bound to CD27(+)CD56(bright) NK cells. While soluble CD70 protein enhanced IFN-γ secretion by CD56(bright) NK cells in the presence of IL-12, it augmented neither cytolytic activity nor proliferation of NK cells. Thus, we next asked if soluble CD70 protein could be used to induce non-cytolytic antiviral activity of NK cells using an in vitro hepatitis C virus (HCV) infection system. Soluble CD70 protein stimulated NK cells to suppress HCV replication by enhancing NK cell IFN-γ secretion without killing infected cells. Taken together, we demonstrate that CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56(bright) NK cells by IFN-γ secretion. Thus, this soluble CD70 protein may be useful for the treatment of viral infections such as HCV infection. |
| File Format | HTM / HTML |
| ISSN | 15216616 |
| Issue Number | 3 |
| Volume Number | 149 |
| e-ISSN | 15217035 |
| Journal | Clinical Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Antigens, Cd27 Immunology Antigens, Cd56 Antigens, Cd70 Pharmacology Antiviral Agents Interferon-gamma Secretion Killer Cells, Natural Drug Effects Genetics Gene Expression Hepacivirus Humans Interleukin-12 Virology Primary Cell Culture Recombinant Proteins Signal Transduction Solubility Virus Replication Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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