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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ko, Myoung Seok Kim, Hyo Jeong Kim, Hong Kyung Yoon, Nal Ae Lee, Unn Hwa Lee, Sang Chul Chung, Dae Kyun Lee, Byung Ju Suh, Jae Hee Cho, Wha Ja Park, Jeong Woo |
| Description | Country affiliation: South Korea Author Affiliation: Ko MS ( Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea); Kim HJ ( Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.); Kim HK ( Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.); Yoon NA ( Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.); Lee UH ( Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.); Lee SC ( Personalized Medicine System R&D Center, Bio-Support Co., Ltd., Anyang, Kyeonggi-Do 431-810, South Korea.); Chung DK ( School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 449-701, South Korea.); Lee BJ ( Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.); Suh JH ( Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, South Korea.); Cho WJ ( Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, South Korea.); Park JW ( Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea. Electronic address: jwpark@ulsan.ac.kr.) |
| Abstract | Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of T(H)17 cells. DRG2 enhanced the activity of PPARγ, which led to an inhibition of the nuclear factor kappa B (NF-κB) activity and IL-6 production in antigen presenting cells and an inhibition of the development of T(H)17 cells. Our results demonstrate that DRG2 is an essential modulator of EAE. |
| File Format | HTM / HTML |
| ISSN | 15216616 |
| Issue Number | 2 |
| Volume Number | 150 |
| e-ISSN | 15217035 |
| Journal | Clinical Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Encephalomyelitis, Autoimmune, Experimental Genetics Immunology Gtp-binding Proteins Th17 Cells Animals Antigen-presenting Cells Metabolism Cell Differentiation Co-repressor Proteins Cytokines Gene Expression Genotype Inflammation Mediators Interleukin-6 Male Mice Mice, Transgenic Nf-kappa B Ppar Gamma Promoter Regions, Genetic Protein Binding T-lymphocyte Subsets Cytology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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