NDLI: T cell epitope mimicry between Sjögren's syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria.

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T cell epitope mimicry between Sjögren's syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Szymula, Agnieszka Rosenthal, Jacob Szczerba, Barbara M. Bagavant, Harini Fu, Shu Man Deshmukh, Umesh S.
Description	Country affiliation: United States Author Affiliation: Szymula A ( Center for Immunity Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.); Rosenthal J ( Center for Immunity Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.); Szczerba BM ( Center for Immunity Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA.); Bagavant H ( Center for Immunity Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA); Fu SM ( Center for Immunity Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA); Deshmukh US ( Center for Immunity Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, USA)
Abstract	This study was undertaken to test the hypothesis that Sjogren's syndrome Antigen A (SSA)/Ro60-reactive T cells are activated by peptides originating from oral and gut bacteria. T cell hybridomas generated from HLA-DR3 transgenic mice recognized 3 regions on Ro60, with core epitopes mapped to amino acids 228-238, 246-256 and 371-381. BLAST analysis identified several mimicry peptides, originating from human oral, intestinal, skin and vaginal bacteria, as well as environmental bacteria. Amongst these, a peptide from the von Willebrand factor type A domain protein (vWFA) from the oral microbe Capnocytophaga ochracea was the most potent activator. Further, Ro60-reactive T cells were activated by recombinant vWFA protein and whole Escherichia coli expressing this protein. These results demonstrate that peptides derived from normal human microbiota can activate Ro60-reactive T cells. Thus, immune responses to commensal microbiota and opportunistic pathogens should be explored as potential triggers for initiating autoimmunity in SLE and Sjögren's syndrome.
File Format	HTM / HTML
ISSN	15216616
e-ISSN	15217035
DOI	10.1016/j.clim.2014.02.004
Journal	Clinical Immunology
Issue Number	1-2
Volume Number	152
Language	English
Publisher	Elsevier
Publisher Date	2014-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Epitopes, T-lymphocyte Immunology Lupus Erythematosus, Systemic Molecular Mimicry Ribonucleoproteins Sjogren's Syndrome Amino Acid Sequence Animals Autoimmunity Capnocytophaga Genetics Cross Reactions Hla-dr3 Antigen Hybridomas Intestines Microbiology Lymphocyte Activation Mice Mouth Peptides Recombinant Proteins Skin T-lymphocytes Vagina Von Willebrand Factor Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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