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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wilhelm, Theresa R. Taddeo, Adriano Winter, Oliver Schulz, Axel Ronald Mälzer, Julia-Nora Domingo, Cristina Biesen, Robert Alexander, Tobias Thiel, Andreas Radbruch, Andreas Hiepe, Falk Gerl, Velia |
| Description | Country affiliation: Germany Author Affiliation: Wilhelm TR ( Ruprecht-Karls-University, Grabengasse 1, 69117 Heidelberg, Germany.); Taddeo A ( Department of Rheumatology and Clinical Immunology, Charité University Hospital, Charitéplatz 1, 10117, Berlin, Germany); Winter O ( Department of Rheumatology and Clinical Immunology, Charité University Hospital, Charitéplatz 1, 10117, Berlin, Germany); Schulz AR ( Regenerative Immunology and Aging, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine CVK, Augustenburger Platz 1, 13353, Berlin, Germany); Mälzer JN ( Regenerative Immunology and Aging, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine CVK, Augustenburger Platz 1, 13353, Berlin, Germany.); Domingo C ( Center for Biological Threats and Special Pathogens 1, Robert Koch-Institute, Nordufer 20, 13353, Berlin, Germany.); Biesen R ( Department of Rheumatology and Clinical Immunology, Charité University Hospital, Charitéplatz 1, 10117, Berlin, Germany.); Alexander T ( Department of Rheumatology and Clinical Immunology, Charité University Hospital, Charitéplatz 1, 10117, Berlin, Germany.); Thiel A ( Regenerative Immunology and Aging, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité University Medicine CVK, Augustenburger Platz 1, 13353, Berlin, Germany.); Radbruch A ( German Rheumatism Research Centre (DRFZ) - a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.); Hiepe F ( Department of Rheumatology and Clinical Immunology, Charité University Hospital, Charitéplatz 1, 10117, Berlin, Germany); Gerl V ( Department of Rheumatology and Clinical Immunology, Charité University Hospital, Charitéplatz 1, 10117, Berlin, Germany) |
| Abstract | Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of systemic lupus erythematosus (SLE) as IFN- producers and promoters of T-cell activation or tolerance. Here, we demonstrated by flow-cytometry and confocal microscopy that Siglec-1, a molecule involved in the regulation of adaptive immunoresponses, is expressed in a subset of semi-mature, myeloid-like pDCs in human blood. These pDCs express lower BDCA-2 and CD123 and higher HLA-DR and CD11c than Siglec-1-negative pDCs and do not produce IFN- via TLR7/TLR9 engagement. In vitro, Siglec-1 expression was induced in Siglec-1-negative pDCs by influenza virus. Proportions of Siglec-1-positive/Siglec-1-negative pDCs were higher in SLE than in healthy controls and correlated with disease activity. Healthy donors immunized with yellow fever vaccine YFV-17D displayed different kinetics of the two pDC subsets during protective immune response. PDCs can be subdivided into two subsets according to Siglec-1 expression. These subsets may play specific roles in (auto)immune responses. |
| File Format | HTM / HTML |
| ISSN | 15216616 |
| Volume Number | 163 |
| e-ISSN | 15217035 |
| Journal | Clinical Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Dendritic Cells Immunology Influenza Vaccines Pharmacology Lupus Erythematosus, Systemic Sialic Acid Binding Ig-like Lectin 1 Metabolism Yellow Fever Vaccine Adult Autoimmune Diseases Autoimmunity Case-control Studies Drug Effects Female Flow Cytometry Humans Immunophenotyping In Vitro Techniques Interferon-alpha Microscopy, Confocal Microscopy, Fluorescence Middle Aged Myeloid Cells Toll-like Receptor 9 Young Adult Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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