NDLI: A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pillet, Stéphane Aubin, Éric Trépanier, Sonia Bussière, Diane Dargis, Michèle Poulin, Jean-François Yassine-Diab, Bader Ward, Brian J. Landry, Nathalie
Description	Author Affiliation: Pillet S ( Medicago Inc., 1020 route de l'Église office 600, Québec, QC, Canada, G1V 3V9); Aubin É ( Medicago Inc., 1020 route de l'Église office 600, Québec, QC, Canada, G1V 3V9.); Trépanier S ( Medicago Inc., 1020 route de l'Église office 600, Québec, QC, Canada, G1V 3V9.); Bussière D ( Medicago Inc., 1020 route de l'Église office 600, Québec, QC, Canada, G1V 3V9.); Dargis M ( Medicago Inc., 1020 route de l'Église office 600, Québec, QC, Canada, G1V 3V9.); Poulin JF ( ImmuneCarta, 201 Avenue du Président-Kennedy, Montreal, QC, Canada, H2X 3Y7.); Yassine-Diab B ( ImmuneCarta, 201 Avenue du Président-Kennedy, Montreal, QC, Canada, H2X 3Y7.); Ward BJ ( Research Institute of the McGill University Health Centre, 2155 Guy Street, 5th Floor, Montreal, QC, Canada, H3H 2R9.); Landry N ( Medicago Inc., 1020 route de l'Église office 600, Québec, QC, Canada, G1V 3V9. Electronic address: Landryn@medicago.com.)
Abstract	Recent issues regarding efficacy of influenza vaccines have re-emphasized the need of new approaches to face this major public health issue. In a phase 1-2 clinical trial, healthy adults received one intramuscular dose of a seasonal influenza plant-based quadrivalent virus-like particle (QVLP) vaccine or placebo. The hemagglutination inhibition (HI) titers met all the European licensure criteria for the type A influenza strains at the 3µg/strain dose and for all four strains at the higher dosages 21days after immunization. High HI titers were maintained for most of the strains 6months after vaccination. QVLP vaccine induced a substantial and sustained increase of hemagglutinin-specific polyfunctional CD4 T cells, mainly transitional memory and TEMRA effector IFN-Î³(+) CD4 T cells. A T cells cross-reactive response was also observed against A/Hong-Kong/1/1968 H3N2 and B/Massachusetts/2/2012. Plant-based QVLP offers an attractive alternative manufacturing method for producing effective and HA-strain matching seasonal influenza vaccines.
File Format	HTM / HTML
ISSN	15216616
Journal	Clinical Immunology
Volume Number	168
e-ISSN	15217035
Language	English
Publisher	Elsevier
Publisher Date	2016-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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