NDLI: Full correction and Undercorrection of Myopia Evaluation Trial: design and baseline data of a randomized, controlled, double-blind trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Shi-Ming Li, Si-Yuan Liu, Luo-Ru Guo, Ji-Yuan Chen, Wei Wang, Ning-Li Millodot, Michel
Description	Country affiliation: China Author Affiliation: Li SM ( Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.)
Abstract	BACKGROUND: To determine the difference in the rate of myopic progression between children wearing single vision lenses with undercorrection of +0.50 D and children whose myopia is fully corrected, and to explore the factors that may influence the process. DESIGN: Randomized, controlled, double-blind trial. PARTICIPANTS: Two hundred children aged 7-15 years with low-to-moderate myopia (-1.5 D to -6.0 D), astigmatism <-1.5 D and anisometropia <1.0 D. METHODS: The children were randomly allocated to wear single vision lenses with full correction or undercorrection by +0.50 D. Ocular examinations and questionnaire surveys for myopia-related factors will be performed every 6 months. MAIN OUTCOME MEASURES: Cycloplegic autorefraction and axial length. RESULTS: Of 200 children, 100 (50%) were girls, 41 (21%) esophoric and 82 (42%) exophoric at near. The characteristics of gender, age, age of myopia onset, phoria, eye dominance, parental myopia, refractive error, axial length, corneal curvature, mean time spent in near work and outdoor activities between the two groups were not significantly different. The accommodative responses at 33 cm, the accommodative demands and lags at infinity were significantly different in the two groups as they were measured with full correction in one group and undercorrection in the other. CONCLUSION: Full correction and Undercorrection of Myopia Evaluation Trial is a clinical trial designed to determine the effectiveness of undercorrection of myopia by +0.5 D on myopic progression in a population of school-aged children known to be susceptible to myopia and to identify the factors influencing the process.
File Format	HTM / HTML
ISSN	14426404
Issue Number	4
Volume Number	41
e-ISSN	14429071
Journal	Clinical & Experimental Ophthalmology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-05-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ophthalmology Eyeglasses Myopia Therapy Accommodation, Ocular Physiology Adolescent Axial Length, Eye Physiopathology Biometry Child Disease Progression Double-blind Method Female Humans Male Diagnosis Refraction, Ocular Research Design Questionnaires Treatment Outcome Visual Acuity Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Ophthalmology

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