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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | El-Sayyad, Hassan I. H. Khalifa, Soad A. El-Sayyad, Fawkia I. Mousa, Shaker A. Mohammed, Ezaldin A. M. |
| Description | Country affiliation: Egypt Author Affiliation: El-Sayyad HI ( Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt.) |
| Abstract | BACKGROUND: Aging is a biological phenomenon that involves an increase of oxidative stress associated with gradual degradation of the structure and function of the retina. Gender differences and subsequent deterioration of retinal cell layers is an interesting topic, especially because there is no published work concerning it. METHODS: One hundred and twenty male and female Wistar albino rats ages 1, 6, 18, 30 and 42 months (n = 20 equal for male and female) were used. At the time interval, retinae were investigated by light and transmission electron microscopy, assessments of neurotransmitters, anti-oxidant enzymes (catalase, superoxide dismustase and glutathione S transferase), caspase-3 and -7, malonadialdhyde, and DNA fragmentation. RESULTS: Light and transmission electron microscopy observations of the older specimens (30 and 42 months) revealed apparent deterioration of retinal cell layers, especially ganglion and nerve fibres, nuclear, pigmented epithelium and stacked membranes of the photoreceptor's outer segments. Males were highly susceptible to aging processes. Retinal DNA fragmentation was remarked parallel with increase of apoptic markers caspase 3 and 7. Concomitantly, there was a marked reduction of neurotransmitters and anti-oxidant enzymes, and an increase of lipid peroxidation. CONCLUSIONS: Aging contributed to an increase of oxidative stress resulting from damage of mitochondria in retinal cells, a decrease of the anti-oxidant enzyme system and an increase of markers of retinal cell death. |
| File Format | HTM / HTML |
| ISSN | 14426404 |
| Issue Number | 2 |
| Volume Number | 42 |
| e-ISSN | 14429071 |
| Journal | Clinical & Experimental Ophthalmology |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-03-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Aging Physiology Eye Proteins Metabolism Retina Ultrastructure Animals Apoptosis Caspase 3 Caspase 7 Cell Count Comet Assay Dna Damage Female Lipid Peroxidation Male Malondialdehyde Microscopy, Electron, Transmission Neurotransmitter Agents Oxidative Stress Oxidoreductases Rats Rats, Wistar Thiobarbituric Acid Reactive Substances Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
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