NDLI: Long-term interleukin-10 presence induces the development of a novel, monocyte-derived cell type.

Please wait, while we are loading the content...

Stimulation by means of dendritic cells followed by Epstein-Barr virus-transformed B cells as antigen-presenting cells is more efficient than dendritic cells alone in inducing Aspergillus f16-specific cytotoxic T cell responses.

Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration.

L-ficolin binding and lectin pathway activation by acetylated low-density lipoprotein.

Multiple-antigen immunization of chickens facilitates the generation of recombinant antibodies to autoantigens.

Lipopolysaccharide augments the in vivo lethal action of doxorubicin against mice via hepatic damage.

Human T cells stimulate fibroblast-mediated degradation of extracellular matrix in vitro.

Association of TNF polymorphisms with sarcoidosis, its prognosis and tumour necrosis factor (TNF)-alpha levels in Asian Indians.

Persistent of respiratory syncytial virus in human dendritic cells and influence of nitric oxide.

The pyrimidin analogue cyclopentenyl cytosine induces alloantigen-specific non-responsiveness of human T lymphocytes.

Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells

Long-term interleukin-10 presence induces the development of a novel, monocyte-derived cell type.

Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis.

Translational mini-review series on complement factor H: therapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis.

Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by lipopolysaccharide endotoxaemia in a rat.

T cell activation profiles in Kawasaki syndrome.

High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality.

Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals.

Preparing for first-in-man studies: the challenges for translational immunology post-TGN1412.

Basal lymphoid aggregates in ulcerative colitis colon: a site for regulatory T cell action.

Year: 2008 Volume: 151 Issue: 1

Year: 2007 Volume: 150

Long-term interleukin-10 presence induces the development of a novel, monocyte-derived cell type.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schoenbein, C. Docke, W-D Wolk, K. Belbe, G. Hoflich, C. Jung, M. Grutz, G. Sterry, W. Volk, H-D Asadullah, K. Sabat, R.
Description	Country affiliation: Germany Author Affiliation: Schoenbein C ( Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, University Hospital Charité, Berlin, Germany.)
Abstract	Interleukin (IL)-10 is one of the most crucial immunoregulatory cytokines. Its short-term effects have been analysed extensively, but little is known about its long-term effects. This is of considerable importance, as high systemic IL-10 levels are present for long periods in patients with persistent viral infections, certain cancers and in critical care patients. Our study investigated the effects of the long-term presence of IL-10 on human peripheral blood monocytes. In vitro, IL-10 treatment of these cells for 7 days induced the development of a novel cell type characterized by unique phenotypical and functional characteristics. These cells showed high HLA-DR expression and low expression of CD86 and other co-stimulatory molecules on their surface. The mRNA levels of both HLA-DR and CD86 were high, but no intracellular accumulation of CD86 protein was observed. With respect to its function, these cells showed strongly diminished tumour necrosis factor-alpha production following lipopolysaccharide stimulation, strongly diminished allogenic CD4(+) T cell stimulatory capacity, and even induced a hyporesponsive state in CD4(+) T cells. The phenotype remained stable despite the removal of IL-10. In vivo, we found monocytic cells from patients exhibiting this phenotype after long-term IL-10 exposure. These results complement our knowledge further about the biological effects of IL-10 and may provide an explanation for the sustained immunodeficiency in cases of the persistent presence of systemic IL-10.
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
Journal	Clinical & Experimental Immunology
Issue Number	2
Volume Number	151
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology Interleukin-10 Immunology Monocytes Antigen-presenting Cells Antigens, Cd86 Genetics Metabolism Cd4-positive T-lymphocytes Cells, Cultured Gene Expression Regulation Hla-dr Antigens Immunophenotyping Therapeutic Use Isoantigens Lymphocyte Activation Psoriasis Drug Therapy Rna, Messenger Tumor Necrosis Factor-alpha Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.

Allogeneic Mature Human Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in the Presence of IL-15.

IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.

Monocyte-derived dendritic cells from patients with severe forms of chromoblastomycosis induce CD4+ T cell activation in vitro.

Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis.

A novel population of human CD56+ human leucocyte antigen D-related (HLA-DR+) colonic lamina propria cells is associated with inflammation in ulcerative colitis.

HLA monomers as a tool to monitor indirect allorecognition.

Allergic women show reduced T helper type 1 alloresponses to fetal human leucocyte antigen mismatch during pregnancy.

Antigen-specific human T-cell clones: development of clones requiring HLA-DR-compatible presenting cells for stimulation in presence of antigen.

Long-term interleukin-10 presence induces the development of a novel, monocyte-derived cell type.

Similar Documents

T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.

Allogeneic Mature Human Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in the Presence of IL-15.

IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.

Monocyte-derived dendritic cells from patients with severe forms of chromoblastomycosis induce CD4+ T cell activation in vitro.

Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis.

A novel population of human CD56+ human leucocyte antigen D-related (HLA-DR+) colonic lamina propria cells is associated with inflammation in ulcerative colitis.

HLA monomers as a tool to monitor indirect allorecognition.

Allergic women show reduced T helper type 1 alloresponses to fetal human leucocyte antigen mismatch during pregnancy.

Antigen-specific human T-cell clones: development of clones requiring HLA-DR-compatible presenting cells for stimulation in presence of antigen.

Long-term interleukin-10 presence induces the development of a novel, monocyte-derived cell type.