NDLI: Investigating the role of proinflammatory CD16+ monocytes in the pathogenesis of inflammatory bowel disease.

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Investigating the role of proinflammatory CD16+ monocytes in the pathogenesis of inflammatory bowel disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koch, S. Kucharzik, T. Heidemann, J. Nusrat, A. Luegering, A.
Description	Country affiliation: United States Author Affiliation: Koch S ( Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA. skoch2@emory.edu)
Abstract	Infiltrating monocytes and macrophages contribute to the initiation and perpetuation of mucosal inflammation characteristic for human inflammatory bowel disease (IBD). Peripheral blood monocytes expressing the low-affinity Fcgamma receptor CD16 have been identified previously as a major proinflammatory cell population, based on their unique cytokine secretion profile. However, the contribution of these cells to the pathogenesis of inflammatory bowel disease remains to be elucidated. Thus, in this study we investigated whether the peripheral CD16(+) monocyte count correlates with common IBD disease parameters, and whether these cells infiltrate the intestinal mucosa under inflammatory conditions. We observed that CD16(+) peripheral blood monocytes are increased significantly in active Crohn's disease, particularly in patients with high Crohn's disease activity index and colonic involvement. Furthermore, we found that CD16(+) cells are a major contributor to the inflammatory infiltrate in Crohn's disease mucosa, although their spontaneous migration through primary human intestinal endothelial cells is limited. Our data suggest that lamina propria, but not peripheral blood, CD16(+) monocytes are a crucial proinflammatory cell population in IBD, and a potential target for anti-inflammatory therapy.
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
DOI	10.1111/j.1365-2249.2010.04177.x
Journal	Clinical & Experimental Immunology
Issue Number	2
Volume Number	161
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-08-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology Inflammatory Bowel Diseases Etiology Monocytes Immunology Receptors, Igg Metabolism Antibodies, Monoclonal Pharmacology Antigens, Cd11a C-reactive Protein Cell Movement Drug Effects Colitis, Ulcerative Pathology Crohn Disease Diagnosis Endothelial Cells Cytology Gpi-linked Proteins Glucocorticoids Therapeutic Use Intercellular Adhesion Molecule-1 Interleukin-1beta Intestinal Mucosa Intestines Leukocyte Count Nod2 Signaling Adaptor Protein Genetics Tumor Necrosis Factor-alpha Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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