NDLI: Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer.

Please wait, while we are loading the content...

Mechanism of glutamine inhibition of cytosolic phospholipase a2 (cPLA2 ): Evidence of physical interaction between glutamine-Induced mitogen-activated protein kinase phosphatase-1 and cPLA2.

Gender bias in lupus: does immune response initiated in the gut mucosa have a role?

High interindividual variability in the CD4/CD8 T cell ratio and natalizumab concentration levels in the cerebrospinal fluid of patients with multiple sclerosis.

C1 inhibitor deficiency: 2014 United Kingdom consensus document.

Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients.

Citrate modulates lipopolysaccharide-induced monocyte inflammatory responses.

Clinical associations of host genetic variations in the genes of cytokines in critically ill patients.

Galectin isolated from parasite inhibits remission of experimental autoimmune encephalomyelitis by up-regulating autoantibody.

Complement activation and expression during chronic relapsing experimental autoimmune encephalomyelitis in the Biozzi ABH mouse.

Activated natural killer cells accelerate liver damage in patients with chronic hepatitis B virus infection.

Proportions of several types of plasma and urine microparticles are increased in patients with rheumatoid arthritis with active disease.

Neutrophil extracellular trap formation is associated with autophagy-related signalling in ANCA-associated vasculitis.

Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer.

Maternal plasma and breastmilk viral loads are associated with HIV-1-specific cellular immune responses among HIV-1-exposed, uninfected infants in Kenya.

Novel therapies for memory cells in autoimmune diseases.

Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes.

Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells.

The complex pathophysiology of acquired aplastic anaemia.

Specific overexpression of tumour necrosis factor- -induced protein (TNFAIP)9 in CD14(+) CD16(-) monocytes in patients with rheumatoid arthritis: comparative analysis with TNFAIP3.

CD11c(+) macrophages and levels of TNF- and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidaemia.

Clonotypically similar hybrid ß T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.

Year: 2015 Volume: 180 Issue: 2

Year: 2015 Volume: 180 Issue: 1

Year: 2015 Volume: 179

Year: 2014 Volume: 178

Year: 2014 Volume: 177

Year: 2014 Volume: 176

Year: 2014 Volume: 175

Year: 2013 Volume: 174

Year: 2013 Volume: 173

Year: 2012 Volume: 169

Year: 2012 Volume: 168

Year: 2011 Volume: 164

Year: 2010 Volume: 162

Year: 2010 Volume: 161

Year: 2010 Volume: 160

Year: 2010 Volume: 159

Year: 2009 Volume: 158

Year: 2009 Volume: 157

Year: 2009 Volume: 156

Year: 2009 Volume: 155

Year: 2008 Volume: 154

Year: 2008 Volume: 153

Year: 2008 Volume: 152

Year: 2008 Volume: 151

Year: 2007 Volume: 150

Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schneider, T. Sevko, A. Heussel, C. P. Umansky, L. Beckhove, P. Dienemann, H. Safi, S. Utikal, J. Hoffmann, H. Umansky, V.
Description	Country affiliation: Germany Author Affiliation: Schneider T ( Department of Thoracic Surgery, St Vincentius Kliniken, Karlsruhe, Germany.); Sevko A ( Skin Cancer Unit, German Cancer Research Center, Heidelberg and Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Heidelberg, Germany.); Heussel CP ( Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik, Heidelberg University, Heidelberg, Germany.); Umansky L ( Department of Translational Immunology, German Cancer Research Center, Heidelberg, Germany.); Beckhove P ( Department of Translational Immunology, German Cancer Research Center, Heidelberg, Germany.); Dienemann H ( Department of Thoracic Surgery, Thoraxklinik, Heidelberg University, Heidelberg, Germany.); Safi S ( Department of Thoracic Surgery, Thoraxklinik, Heidelberg University, Heidelberg, Germany.); Utikal J ( Skin Cancer Unit, German Cancer Research Center, Heidelberg and Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Heidelberg, Germany.); Hoffmann H ( Department of Thoracic Surgery, Thoraxklinik, Heidelberg University, Heidelberg, Germany.); Umansky V ( Skin Cancer Unit, German Cancer Research Center, Heidelberg and Department of Dermatology, Venerology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Heidelberg, Germany.)
Abstract	In recent years, percutaneous radiofrequency ablation (RFA) has been developed as a new tool in the treatment of non-small-cell lung cancer (NSCLC) in non-surgical patients. There is growing evidence that RFA-mediated necrosis can modulate host immune responses. Here we analysed serum inflammatory factors as well as immunosuppressive cells in the peripheral blood to discover possible prognostic indicators. Peripheral blood and serum samples were collected before RFA and within 3 months after the treatment in a total of 12 patients. Inflammatory cytokines and growth factors were measured in serum by the Bio-Plex assay. Myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs ) were evaluated in the peripheral blood via flow cytometry. In patients developing local or lymphogenic tumour relapse (n=4), we found an early significant increase in the concentration of tumour necrosis factor (TNF)- as well as chemokine (C-C motif) ligand (CCL)-2 and CCL-4 compared to patients without relapse (n=4) and healthy donors (n=5). These changes were associated with an elevated activity of circulating MDSC indicated by an increased nitric oxide (NO) production in these cells. Elevated serum levels of TNF- , CCL-2 and CCL-4 associated with an increased NO production in circulating MDSCs might be an early indicator of the incomplete RFA and subsequently a potential tumour relapse in NSCLC.
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
DOI	10.1111/cei.12596
Journal	Clinical & Experimental Immunology
Issue Number	3
Volume Number	180
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology Carcinoma, Non-small-cell Lung Blood Immunology Inflammation Mediators Lung Neoplasms Myeloid Cells Biological Markers Diagnosis Surgery Catheter Ablation Cell Count Positron-emission Tomography Prognosis Tomography, X-ray Computed Tumor Burden
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer

Radiofrequency ablation for primary lung cancer and pulmonary metastases.

Value of C-arm computed tomography in radiofrequency ablation of small lung lesions.

Positron Emission Tomography-Based Short-Term Efficacy Evaluation and Prediction in Patients With Non-Small Cell Lung Cancer Treated With Hypo-Fractionated Radiotherapy

Thorax radiotherapy using 18F-positron emission tomography/computed tomography-guided precision radiotherapy is a prognostic factor for survival in patients with extracranial oligometastatic non-small cell lung cancer:A two-center propensity score-matched analysis

A new PET/CT volumetric prognostic index for non-small cell lung cancer.

Negative predictive value of positron emission tomography and computed tomography for stage T1-2N0 non-small-cell lung cancer: a meta-analysis.

Computed Tomography-Guided Percutaneous Radiofrequency Ablation in Older Adults With Early-Stage Peripheral Lung Cancer: A Retrospective Cohort Study

Metabolic Burden Measured by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Is a Prognostic Factor in Patients with Small Cell Lung Cancer

Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer.

Similar Documents

Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer

Radiofrequency ablation for primary lung cancer and pulmonary metastases.

Value of C-arm computed tomography in radiofrequency ablation of small lung lesions.

Positron Emission Tomography-Based Short-Term Efficacy Evaluation and Prediction in Patients With Non-Small Cell Lung Cancer Treated With Hypo-Fractionated Radiotherapy

Thorax radiotherapy using 18F-positron emission tomography/computed tomography-guided precision radiotherapy is a prognostic factor for survival in patients with extracranial oligometastatic non-small cell lung cancer:A two-center propensity score-matched analysis

A new PET/CT volumetric prognostic index for non-small cell lung cancer.

Negative predictive value of positron emission tomography and computed tomography for stage T1-2N0 non-small-cell lung cancer: a meta-analysis.

Computed Tomography-Guided Percutaneous Radiofrequency Ablation in Older Adults With Early-Stage Peripheral Lung Cancer: A Retrospective Cohort Study

Metabolic Burden Measured by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Is a Prognostic Factor in Patients with Small Cell Lung Cancer

Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer.