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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Theil, A. Wilhelm, C. Kuhn, M. Petzold, A. Tuve, S. Oelschlägel, U. Dahl, A. Bornhäuser, M. Bonifacio, E. Eugster, A. |
| Description | Country affiliation: Germany Author Affiliation: Theil A ( DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.); Wilhelm C ( Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.); Kuhn M ( DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.); Petzold A ( Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, Dresden, Germany.); Tuve S ( Deep Sequencing Group, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.); Oelschlägel U ( Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.); Dahl A ( Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.); Bornhäuser M ( Deep Sequencing Group, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.); Bonifacio E ( Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.); Eugster A ( DFG-Center for Regenerative Therapies Dresden, Dresden, Germany.) |
| Abstract | Regulatory T cell (T ) therapy has been exploited in autoimmune disease, solid organ transplantation and in efforts to prevent or treat graft-versus-host disease (GVHD). However, our knowledge on the in-vivo persistence of transfused T is limited. Whether T transfusion leads to notable changes in the overall T repertoire or whether longevity of T in the periphery is restricted to certain clones is unknown. Here we use T cell receptor alpha chain sequencing (TCR- -NGS) to monitor changes in the repertoire of T upon polyclonal expansion and after subsequent adoptive transfer. We applied TCR- -NGS to samples from two patients with chronic GVHD who received comparable doses of stem cell donor derived expanded T . We found that in-vitro polyclonal expansion led to notable repertoire changes in vitro and that T cell therapy altered the peripheral T repertoire considerably towards that of the infused cell product, to different degrees, in each patient. Clonal changes in the peripheral blood were transient and correlated well with the clinical parameters. We suggest that T cell clonotype analyses using TCR sequencing should be considered as a means to monitor longevity and fate of adoptively transferred T cells. |
| File Format | HTM / HTML |
| ISSN | 00099104 |
| Issue Number | 2 |
| Journal | Clinical & Experimental Immunology |
| Volume Number | 187 |
| e-ISSN | 13652249 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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