NDLI: Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Matricardi, P. M. Bockelbrink, A. Keil, T. Grüber, C. Niggemann, B. Hamelmann, E. Wahn, U. Lau, S.
Spatial Coverage	Germany
Description	Country affiliation: Germany Author Affiliation: Matricardi PM ( Department of Pediatric Pneumology and Immunology, Charité-Universitätsmedizin, Berlin, Germany. paolo.matricardi@charite.de)
Abstract	BACKGROUND: Allergic rhinoconjunctivitis and asthma evolve dynamically throughout childhood. Yet, data on the evolution of serum levels of IgE antibodies against airborne allergens throughout the first decade of life are scarce. OBJECTIVE: To describe the patterns of new and persistent sensitization against airborne allergens including remission from birth to 10 years of age and the long-term clinical outcomes up to the age of 13 years. METHODS: In 273 children from the Multi-Centre Allergy Study, a German birth cohort, IgE levels were determined against airborne allergens (Dermatophagoides pteronyssinus, cat and dog dander, birch and grass species pollens) at 2, 5, 7, and 10 years of age (ImmunoCAP, Phadia); allergic rhino-conjunctivitis and asthma were ascertained at the 13 years of age through a standardized questionnaire (International Study of Asthma and Allergies in Childhood). RESULTS: The prevalence of sensitization to each allergen increased steadily throughout childhood, and a hierarchy of sensitization prevalence (grass>birch>mites>cat>dog) was maintained from 5 years of age onwards. A mono-sensitization state was relatively short (measurable half-life=3 years) as additional sensitizations were acquired frequently, and relatively soon after the first one. Remission of weak sensitization (UNICAP classes 1-2) was also quite frequent, especially before 5 years of age. By contrast, stronger IgE responses (>3.5 kU/L) were invariably persistent. Early sensitization was associated with a higher tendency for poly-sensitization at 10 years of age and allergic rhino-conjunctivitis and/or asthma at 13 years of age. CONCLUSIONS: IgE responses against airborne allergens undergo dynamic changes throughout childhood, with a high frequency of new sensitization or remission. The long-term persistence and the clinical impact of IgE responses are affected by the intensity of IgE sensitization and the age of its onset.
File Format	HTM / HTML
ISSN	09547894
Issue Number	10
Volume Number	39
e-ISSN	13652222
Journal	Clinical & Experimental Allergy
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Allergens Hypersensitivity Blood Immunoglobulin E Questionnaires Adolescent Animals Cats Child Child, Preschool Dogs Female Germany Humans Epidemiology Infant Infant, Newborn Male Prospective Studies Journal Article Multicenter Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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