NDLI: A novel synthetic lipopeptide is allergy-protective by the induction of LPS-tolerance.

Please wait, while we are loading the content...

Year: 2017 Volume: 47

Year: 2016 Volume: 46

Year: 2015 Volume: 45

Year: 2014 Volume: 44

Year: 2013 Volume: 43

Year: 2013 Volume: 43 Issue: 12

Year: 2013 Volume: 43 Issue: 11

Year: 2013 Volume: 43 Issue: 10

Year: 2013 Volume: 43 Issue: 9

Year: 2013 Volume: 43 Issue: 8

Year: 2013 Volume: 43 Issue: 7

Fishing for allergy prevention.

Weight loss in children with asthma improves asthma control and quality of life.

Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions.

Role of CCL18 in asthma and lung immunity.

Specialist-based treatment reduces the severity of allergic rhinitis.

Eosinophil activation and novel mediators in the aspirin-induced nasal response in AERD.

Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE-dependent secretion from human lung mast cells.

ZAP70 expression in regulatory T cells in allergic rhinitis: effect of immunotherapy.

Dampness and moulds in relation to respiratory and allergic symptoms in children: results from Phase Two of the International Study of Asthma and Allergies in Childhood (ISAAC Phase Two).

Diet-induced weight loss in obese children with asthma: a randomized controlled trial.

A novel synthetic lipopeptide is allergy-protective by the induction of LPS-tolerance.

Dietary long chain n-3 polyunsaturated fatty acids prevent allergic sensitization to cow's milk protein in mice.

Identification of enolases and aldolases as important fish allergens in cod, salmon and tuna: component resolved diagnosis using parvalbumin and the new allergens.

Year: 2013 Volume: 43 Issue: 6

Year: 2013 Volume: 43 Issue: 5

Year: 2013 Volume: 43 Issue: 4

Year: 2013 Volume: 43 Issue: 3

Year: 2013 Volume: 43 Issue: 2

Year: 2013 Volume: 43 Issue: 1

Year: 2012 Volume: 42

Year: 2011 Volume: 41

Year: 2010 Volume: 40

Year: 2009 Volume: 39

Year: 2008 Volume: 38

A novel synthetic lipopeptide is allergy-protective by the induction of LPS-tolerance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stiehm, M. Peters, K. Wiesmüller, K-H Bufe, A. Peters, M.
Description	Country affiliation: Germany Author Affiliation: Stiehm M ( Department of Experimental Pneumology, Ruhr-University Bochum, Bochum, Germany.)
Abstract	BACKGROUND: Exposure to the environment of traditional farms can protect children from some allergic disease. Due to this exposure, TLR2 expression in these children is increased. TLR2 ligands derived from gram-positive bacteria are found in the dust of these farms. OBJECTIVES: We proved whether a synthetic lipopeptide binding to the TLR1/2 heterodimer is able to protect from allergic disease in two different murine models of allergy. We also investigated the immunological mechanisms underlying the protective properties of the lipopeptide. METHODS: We synthesized a lipopeptide derived from a germination lipoprotein of Bacillus cereus (LPGerD). We evaluated the immunomodulatory activity of LPGerD in a murine model of systemic sensitization (OVA/Alum) and in a model in which mice were sensitized with OVA pulsed bone-marrow-derived dendritic cells (BMDCs) via the airways. Furthermore, the induction of LPS tolerance was studied. RESULTS: Treatment of mice with LPGerD in a mouse model of asthma led to protection against sensitization and airway inflammation. Similarly, bone-marrow-derived dendritic cells (BMDCs) pre-treated with LPGerD were not able to prime mice for allergic immune response. We observed that pre-treatment with LPGerD led to the induction of a LPS-tolerant state in BMDCs. These cells secreted markedly lower amounts of pro-inflammatory cytokines upon LPS stimulation. Furthermore, we observed an up-regulation of IRAK-M mRNA in BMDCs pre-treated with LPGerD. CONCLUSIONS AND CLINICAL RELEVANCE: Our results suggest that induction of a LPS-tolerant state in antigen-presenting cells (APCs) may contribute to the protective effect of a farming environment. TLR2 agonists similar to those appearing in cowshed dust extracts, such as our synthetic LPGerD, lead to the ignorance of the LPS stimulus, which is important for the activation of APCs to mount a Th2 immune response. This substance might be a promising candidate for allergy-preventive treatments as LPGerD had only low pro-inflammatory characteristics.
File Format	HTM / HTML
ISSN	09547894
Issue Number	7
Volume Number	43
e-ISSN	13652222
Journal	Clinical & Experimental Allergy
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-07-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Asthma Drug Therapy Bacillus Cereus Chemistry Bacterial Proteins Immune Tolerance Drug Effects Lipopeptides Lipopolysaccharides Toxicity Animals Chemically Induced Immunology Chemical Synthesis Pharmacology Bone Marrow Cells Pathology Dendritic Cells Disease Models, Animal Female Genetics Mice Mice, Inbred Balb C Mice, Knockout Toll-like Receptor 1 Agonists Toll-like Receptor 2 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in