NDLI: Relationships between T cell and IgE/IgG4 epitopes of the Anisakis simplex major allergen Ani s 1.

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Relationships between T cell and IgE/IgG4 epitopes of the Anisakis simplex major allergen Ani s 1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Garcia Alonso, M. Caballero, M. L. Umpierrez, A. Lluch-Bernal, M. Knaute, T. Rodríguez-Pérez, R.
Description	Country affiliation: Spain Author Affiliation: Garcia Alonso M ( Hospital La Paz Institute for Health Research, IdiPaz, Madrid, Spain.)
Abstract	BACKGROUND: Anisakiasis is a global disease caused by the consumption of raw or lightly cooked fish parasitized with third-stage Anisakis larvae. Anisakis simplex allergens may cause severe allergic reactions including angio-oedema, urticaria and anaphylaxis. Approximately 80% of allergic patients have allergen-specific IgE against Ani s 1, and the diagnostic value of testing for antibodies to Ani s 1 has been extensively demonstrated. However, no previous studies have investigated the molecular aspects of the allergic response to Ani s 1. Knowledge of allergen-specific T cell and B cell (IgE and IgG4) epitopes is important for elucidating the immunological mechanisms underlying allergic responses, and for understanding why particular proteins behave as allergens. OBJECTIVE: To elucidate the main T cell- and B cell (IgE and IgG4)- binding regions of Ani s 1. METHODS: T cell epitopes were identified by peptide proliferation assays using T cell lines derived from peripheral blood mononuclear cells of 11 patients with Anisakis allergy, and IgE and IgG4 epitopes were identified by microarray immunoassay using sera from a different group of 11 patients with Anisakis allergy. RESULTS: Several T cell epitopes of Ani s 1 were identified, of which Ani s 1145-156 , Ani s 1151-162 and Ani s 1163-171 located at the C-terminal end of the protein were the most relevant. IgE and IgG4 recognized largely the same peptides, including Ani s 122-41 , Ani s 125-44 , Ani s 127-47 , Ani s 137-56 and Ani s 194-113 . CONCLUSIONS AND CLINICAL RELEVANCE: This is the first report describing the T cell epitopes of an important allergen of A. simplex, and the first B cell epitope study of this allergen in the Spanish population. This information can help to elucidate the mechanisms underlying the allergic response to Ani s 1, potentially leading to therapeutic and diagnostic advances.
File Format	HTM / HTML
ISSN	09547894
Issue Number	5
Volume Number	45
e-ISSN	13652222
Journal	Clinical & Experimental Allergy
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Allergens Immunology Calcium-binding Proteins Epitopes Helminth Proteins Immunoglobulin E Immunoglobulin G T-lymphocytes Aged Amino Acid Sequence Animals B-lymphocytes Metabolism Cell Line Epitope Mapping Chemistry Epitopes, T-lymphocyte Female Humans Hypersensitivity Male Middle Aged Protein Binding Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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