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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jin, Guang-Zhen Cho, Su-Jin Choi, Eu-Gene Lee, Young-S Yu, Xian-Feng Choi, Kap-Seong Yee, Sung-Tae Jeon, Jin-Tae Kim, Myeong-Ok Kong, Il-Keun |
| Description | Country affiliation: South Korea Author Affiliation: Jin GZ ( Division of Applied Life Science BK21, Institute of Agriculture and Life Science, Graduate School of Gyeongsang National University, Jinju, GyeongNam Province, South Korea.) |
| Abstract | Mesenchymal stem cells (MSCs) are pluripotent adult stem cells. It has been shown that MSCs secrete neurotrophic factors involving nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Also, these neurotrophic factors can upregulate tyrosine hydroxylase (TH) gene expression in PC12 cells and neural stem cells. Here, we investigated the effect of co-culturing rat E13.5 ventral mesencephalic cells (VMCs) with MSCs from rat bone marrow on TH expression and dopamine (DA) content. The study consisted of 3 groups: MSC, VMC and a combined MSC + VMC group. All groups were cultured in serum-free neuro-basal medium for 3 days. Thereafter, each group was analyzed by RT-PCR, western blotting, and HPLC. The co-culture group showed a higher expression at TH and DA than the VMC group. However, TH and DA were not present in the MSC group. These observations suggest that MSCs could be an alternative source for treating neurodegenerative diseases such as Parkinson's disease (PD). |
| File Format | HTM / HTML |
| ISSN | 10656995 |
| Issue Number | 11 |
| Volume Number | 32 |
| e-ISSN | 10958355 |
| Journal | Cell Biology International |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2008-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cell Biology Cell Communication Physiology Dopamine Metabolism Mesencephalon Mesenchymal Stromal Cells Neurons Tyrosine 3-monooxygenase Animals Cells, Cultured Coculture Techniques Male Cytology Mesenchymal Stem Cell Transplantation Methods Secretion Nerve Growth Factors Parkinson Disease Surgery Rats Rats, Sprague-dawley Substantia Nigra Up-regulation Ventral Tegmental Area Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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