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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yamasaki, Takuma Deie, Masataka Shinomiya, Rikuo Yasunaga, Yuji Yanada, Shinobu Ochi, Mitsuo |
| Description | Country affiliation: Japan Author Affiliation: Yamasaki T ( Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. tacyama@hiroshima-u.ac.jp) |
| Abstract | The purpose of this study was to assess transplantation of regenerated menisci using scaffolds from normal allogeneic menisci and bone-marrow-derived mesenchymal stromal cells (BM-MSCs) of rats. We reported that scaffolds derived from normal menisci seeded with BM-MSCs in vitro could form meniscal tissues within 4 weeks. Then, we hypothesized that our tissues could be more beneficial than allogeneic menisci regarding early maturation and chondroprotective effect. Bone marrow was aspirated from enhanced green fluorescent protein transgenic rats. BM-MSCs were isolated and seeded onto scaffolds which were prepared from Sprague-Dawley rat menisci. After 4 weeks in coculture, the tissues were transplanted to the defect of menisci. Repopulation of BM-MSCs and expression of extracellular matrices were observed in the transplanted tissues at 4 weeks after surgery. At 8 weeks, articular cartilage in the cell-free group was more damaged compared to that in the cell-seeded group or the meniscectomy group. |
| File Format | HTM / HTML |
| ISSN | 0160564X |
| Issue Number | 7 |
| Volume Number | 32 |
| e-ISSN | 15251594 |
| Journal | Artificial Organs |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Transplantation Bone Marrow Cells Cytology Physiology Guided Tissue Regeneration Menisci, Tibial Transplantation Mesenchymal Stromal Cells Tissue Engineering Tissue Scaffolds Animals Animals, Genetically Modified Cells, Cultured Extracellular Matrix Green Fluorescent Proteins Metabolism Male Rats Rats, Sprague-dawley Regeneration Stromal Cells Tissue Culture Techniques Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biomaterials Bioengineering Biomedical Engineering |
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