NDLI: Light-activated cytotoxic compounds from Malaysian microorganisms for photodynamic therapy of cancer.

Please wait, while we are loading the content...

Light-activated cytotoxic compounds from Malaysian microorganisms for photodynamic therapy of cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kamal, Nurkhalida Sabaratnam, Vikineswary Abdullah, Noorlidah Ho, Anthony S. H. Teo, Soo H. Lee, Hong B.
Spatial Coverage	Malaysia
Description	Country affiliation: Malaysia Author Affiliation: Kamal N ( Cancer Research Initiatives Foundation (CARIF), Level 2 Outpatient Centre, Subang Jaya Medical Centre, No 1 Jalan SS12/1A, 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia.)
Abstract	Photodynamic therapy (PDT) is a promising cancer treatment which involves activation of a photosensitizing drug with light to produce reactive oxygen species that kill tumors without causing damage to unirradiated normal tissues. To date, only Photofrin, Foscan and Levulan have been approved for clinical treatment of cancer. Tropical habitats such as those found in Malaysia are attractive sources of new therapeutic compounds as tremendous chemical diversity is found in a large number of plants, animals, marine- and micro-organisms. In our screening program for novel photosensitizers from nature, colorful strains of fungi (from Aspergillus and Penicillium genus) and bacteria (including actinomycetes and photosynthetic bacteria) were collected from various habitats in Peninsular Malaysia, such as coastal soil, peat soil, marine sponges and wastewater ponds. Methanolic extracts from a total of 85 different species were evaluated with a short-term cell viability assay for photo-cytotoxicity, where a promyelocytic leukemia cell-line, HL60 incubated with 20 microg/ml of extracts was irradiated with 9.6 J/cm(2) of a broad spectrum light. Two of these extracts, one from Rhodobacter sphaeroides (PBUM003) and one from Rhodopseudomonas palustris (PBUM001) showed moderate to strong photo-cytotoxicity. Subsequent bioassay guided isolation of the PBUM001 extract yielded known photosensitisers that are based on bacteriochlorophyll-a by comparing their molecular weight data, HPLC profiles and UV-vis absorption spectra with literature values, thereby demonstrating the validity of our screening approach.
File Format	HTM / HTML
ISSN	00036072
Issue Number	2
Volume Number	95
e-ISSN	15729699
Journal	Antonie van Leeuwenhoek
Language	English
Publisher	Springer
Publisher Date	2009-02-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Microbiology Discipline Immunology Antineoplastic Agents Isolation & Purification Pharmacology Bacteria Chemistry Fungi Photochemotherapy Porifera Microbiology Soil Microbiology Water Microbiology Animals Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Humans Light Malaysia Spectrophotometry, Ultraviolet Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Microbiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Light-activated cytotoxic compounds from Malaysian microorganisms for photodynamic therapy of cancer

Cytotoxic constituents from the bark of Salix hulteni.

JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.

The cytotoxic and antifungal activities of two new sesquiterpenes, malfilanol A and B, derived from Malbranchea filamentosa.

Isolation, Purification, and Structural Identification of an Antifungal Compound from a Trichoderma Strain.

PM070747, a new cytotoxic angucyclinone from the marine-derived Saccharopolyspora taberi PEM-06-F23-019B.

Anti-proliferative effect of fungal taxol extracted from Cladosporium oxysporum against human pathogenic bacteria and human colon cancer cell line HCT 15.

Isolation and characterization of marine pigmented bacteria from Norwegian coastal waters and screening for carotenoids with UVA-blue light absorbing properties.

Cystodienoic acid: a new diterpene isolated from the myxobacterium Cystobacter sp.

Light-activated cytotoxic compounds from Malaysian microorganisms for photodynamic therapy of cancer.

Similar Documents

Light-activated cytotoxic compounds from Malaysian microorganisms for photodynamic therapy of cancer

Cytotoxic constituents from the bark of Salix hulteni.

JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.

The cytotoxic and antifungal activities of two new sesquiterpenes, malfilanol A and B, derived from Malbranchea filamentosa.

Isolation, Purification, and Structural Identification of an Antifungal Compound from a Trichoderma Strain.

PM070747, a new cytotoxic angucyclinone from the marine-derived Saccharopolyspora taberi PEM-06-F23-019B.

Anti-proliferative effect of fungal taxol extracted from Cladosporium oxysporum against human pathogenic bacteria and human colon cancer cell line HCT 15.

Isolation and characterization of marine pigmented bacteria from Norwegian coastal waters and screening for carotenoids with UVA-blue light absorbing properties.

Cystodienoic acid: a new diterpene isolated from the myxobacterium Cystobacter sp.

Light-activated cytotoxic compounds from Malaysian microorganisms for photodynamic therapy of cancer.