NDLI: Primary and Secondary Hepatic Lymphomas Diagnosed by Image-Guided Fine-Needle Aspiration: A Retrospective Study of Clinical and Cytomorphologic Findings

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Swadley, Matthew J. Deliu, Matea Mosunjac, Marina B. Gunthel, Clifford J. Nguyen, Minh Ly T. Hanley, Krisztina Z.
Spatial Coverage	Georgia
Description	Author Affiliation: Swadley MJ ( Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Room H185C, Atlanta, GA 30322)
Abstract	Objectives: To explore the diagnosis of hematolymphoid malignancies of the liver (hepatic lymphoma [HeL]) by image-guided fine-needle aspiration (FNA), which can often be difficult due to a low index of suspicion and nonspecific patient presentations, especially in the rare cases where the liver is the only site of disease (primary HeL [PHeL]). Understanding the clinical setting in which such lesions arise, as well as the cytomorphologic findings, may assist cytopathologists in making an accurate diagnosis and triaging samples for ancillary studies. Methods: In this retrospective study of 32 patients with HeL, the largest such study to our knowledge, we review the clinical and diagnostic features of HeL. Results: HeL and especially PHeL most commonly show a diffuse large B-cell lymphoma phenotype and have a poor prognosis (median survival of seven months). PHeL is strongly associated with human immunodeficiency virus infection (12/16 patients). Conclusions: Image-guided FNA with immediate evaluation is a reliable means to obtain diagnostic material and triage for ancillary tests.
File Format	HTM / HTML
ISSN	00029173
e-ISSN	19437722
Journal	American Journal of Clinical Pathology
Issue Number	1
Volume Number	141
Language	English
Publisher	Oxford University Press
Publisher Date	2014-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Pathology Liver Neoplasms Diagnosis Lymphoma, Large B-cell, Diffuse Biopsy, Fine-needle Georgia Epidemiology Hiv Infections Complications Image-guided Biopsy Mortality Pathology Retrospective Studies Multicenter Study
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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