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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Razmpoosh, Maryam Sansregret, Andrée Oligny, Luc L. Patey, Natalie Dormoy-Raclet, Virginie Ducruet, Thierry Bouron-Dal Soglio, Dorothée |
| Description | Author Affiliation: Razmpoosh M ( From the Department of Pathology.); Sansregret A ( Department of Gyneco-Obstetrics, and.); Oligny LL ( From the Department of Pathology.); Patey N ( From the Department of Pathology.); Dormoy-Raclet V ( Laboratory of Molecular Diagnosis, CHU Sainte-Justine, Université de Montréal, Québec, Canada, and.); Ducruet T ( URCA-CHU Sainte-Justine, Université de Montréal, Québec, Canada.); Bouron-Dal Soglio D ( From the Department of Pathology, edorothee.dal_soglio.hsj@ssss.gouv.qc.ca.) |
| Abstract | Objectives: To study and compare the effectiveness of $p16^{INK4a}$ staining and specific human papillomavirus (HPV) subtypes as a prognostic marker in cervical intraepithelial neoplasia grade 1 (CIN1; low-grade squamous intraepithelial lesions). Methods: Sixty-four cervical samples diagnosed as CIN1 and stained with $p16^{INK4a},$ with HPV status assessed by polymerase chain reaction–direct sequencing. Results: Of the 34 $p16^{INK4a}-negative$ biopsy specimens, 26 regressed, seven persisted, and one progressed. Of the 20 $p16^{INK4a}$ diffusely positive biopsy specimens, seven regressed, eight persisted, and five progressed. Ten biopsy specimens stained positive only in the lower one-third of the sample, of which seven regressed and three persisted. $p16^{INK4a}$ diffusely positive CIN1 lesions were associated with only high-risk HPV subtypes, with the exception of one HPV-negative biopsy specimen. Three different high-risk HPV subtypes and one low-risk HPV subtype (HPV66) were identified in the six CIN1 lesions that progressed. Conclusions: There is a significant relationship between $p16^{INK4a}$ immunostaining and follow-up (P = .002). $p16^{INK4a}-negative$ specimens or positivity in the lower one-third of CIN1 lesions seldom progress to a CIN2-3 lesion. |
| File Format | HTM / HTML |
| ISSN | 00029173 |
| e-ISSN | 19437722 |
| Journal | American Journal of Clinical Pathology |
| Issue Number | 1 |
| Volume Number | 142 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2014-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Pathology Carcinoma, Squamous Cell Virology Cervical Intraepithelial Neoplasia Cyclin-dependent Kinase Inhibitor P16 Metabolism Papillomaviridae Isolation & Purification Papillomavirus Infections Diagnosis Uterine Cervical Neoplasms Tumor Markers, Biological Pathology Disease Progression Prognosis Comparative Study |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pathology and Forensic Medicine |
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