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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pierce, Joseph R. Maples, Jill M. Hickner, Robert C. |
| Description | Author Affiliation: Pierce JR ( Human Performance Laboratory, East Carolina University, Greenville, North Carolina); Maples JM ( Human Performance Laboratory, East Carolina University, Greenville, North Carolina); Hickner RC ( Human Performance Laboratory, East Carolina University, Greenville, North Carolina) |
| Abstract | Animal/cell investigations indicate that there is a decreased adipose tissue mass resulting from skeletal muscle (SkM) IL-15 secretion (e.g., SkM-blood-adipose tissue axis). IL-15 could regulate fat mass accumulation in obesity via lipolysis, although this has not been investigated in humans. Therefore, the purpose was to examine whether SkM and/or subcutaneous adipose tissue (SCAT) IL-15 concentrations were correlated with SCAT lipolysis in lean and obese humans and determine whether IL-15 perfusion could induce lipolysis in human SCAT. Local SkM and abdominal SCAT IL-15 (microdialysis) and circulating IL-15 (blood) were sampled in lean (BMI: 23.1 ± 1.9 kg/m(2); n = 10) and obese (BMI: 34.7 ± 3.5 kg/m(2); n = 10) subjects at rest/during 1-h cycling exercise. Lipolysis (SCAT interstitial glycerol concentration) was compared against local/systemic IL-15. An additional probe in SCAT was perfused with IL-15 to assess direct lipolytic responses. SkM IL-15 was not different between lean and obese subjects (P = 0.45), whereas SCAT IL-15 was higher in obese vs. lean subjects (P = 0.02) and was correlated with SCAT lipolysis (r = 0.45, P = 0.05). Exercise increased SCAT lipolysis in lean and obese (P < 0.01), but exercise-induced SCAT lipolysis changes were not correlated with exercise-induced SCAT IL-15 changes. Microdialysis perfusion resulting in physiological IL-15 concentrations in the adipose tissue interstitium increased lipolysis in lean (P = 0.04) but suppressed lipolysis in obese (P < 0.01). Although we found no support for a human IL-15 SkM-blood-adipose tissue axis, IL-15 may be produced in/act on the abdominal SCAT depot. The extent to which this autocrine/paracrine IL-15 action regulates human body composition remains unknown. |
| File Format | HTM / HTML |
| ISSN | 01931849 |
| e-ISSN | 15221555 |
| DOI | 10.1152/ajpendo.00575.2014 |
| Journal | AJP: Endocrinology and Metabolism |
| Issue Number | 12 |
| Volume Number | 308 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2015-06-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Discipline Metabolism Discipline Endocrinology Adipose Tissue Drug Effects Interleukin-15 Administration & Dosage Lipolysis Muscle, Skeletal Obesity Metabolism Subcutaneous Fat Thinness Adolescent Physiology Microdialysis Blood Chemistry Clinical Trial Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Endocrinology, Diabetes and Metabolism Physiology (medical) |
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