NDLI: Placenta-derived multipotent cells differentiate into neuronal and glial cells in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yen, B. Linju Chien, Chih-Cheng Chen, Yao-Chang Chen, Jen-Tse Huang, Jing-Shan Lee, Fa-Kung Huang, Hsing-I
Description	Country affiliation: Taiwan Author Affiliation: Yen BL ( Stem Cell Research Center, National Health Research Institutes, Taipei, Taiwan.)
Abstract	Stem cells have great potential for clinical application because of their self-renewal property and ability to differentiate into many types of cells, but because there are ethical and biological limitations with current sources of stem cells, the search continues for more suitable sources of multipotent cells. We have reported previously on a population of multipotent cells isolated from the human term placenta, an ethically unproblematic and easily available source of tissue. These placenta-derived multipotent cells (PDMCs) can differentiate into lineages of mesenchymal tissues, including osteoblasts and adipocytes, as well as non-mesenchymal tissue of neuron-like cells. We further examined the ability of PDMCs to differentiate into all 3 types of neural cells--neurons, astrocytes, and oligodendrocytes--under various induction conditions, including retinoic acid (RA), 1-methyl-3-isobutylxanthine (IBMX), and co-culture with neonatal rat brain cells. PDMCs exhibited outgrowth of processes and the expression of neuron-specific molecules such as neuron-specific enolase upon induction. Co-culture with neonatal rat brain cells also induced neural differentiation. Our results indicate that PDMCs can be differentiated into neural cell types of the human nervous system upon exposure to RA, IBMX, or primary rat brain cells.
File Format	HTM / HTML
ISSN	21524947
Issue Number	1
Volume Number	14
e-ISSN	21524955
Journal	Tissue Engineering Part A
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2008-01-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Biotechnology Astrocytes Metabolism Cell Differentiation Physiology Multipotent Stem Cells Neurons Oligodendroglia Placenta 1-methyl-3-isobutylxanthine Pharmacology Adipocytes Cytology Animals Animals, Newborn Antineoplastic Agents Drug Effects Cells, Cultured Coculture Techniques Enzyme Induction Female Humans Osteoblasts Phosphodiesterase Inhibitors Phosphopyruvate Hydratase Biosynthesis Pregnancy Rats Tretinoin Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article

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