NDLI: Nanoclay-enriched poly(É-caprolactone) electrospun scaffolds for osteogenic differentiation of human mesenchymal stem cells.

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Nanoclay-enriched poly(É-caprolactone) electrospun scaffolds for osteogenic differentiation of human mesenchymal stem cells.

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Nanoclay-enriched poly(É-caprolactone) electrospun scaffolds for osteogenic differentiation of human mesenchymal stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gaharwar, Akhilesh K. Mukundan, Shilpaa Karaca, Elif Dolatshahi-Pirouz, Alireza Patel, Alpesh Rangarajan, Kaushik Mihaila, Silvia M. Iviglia, Giorgio Zhang, Hongbin Khademhosseini, Ali
Description	Author Affiliation: Gaharwar AK ( 1 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts.)
Abstract	Musculoskeletal tissue engineering aims at repairing and regenerating damaged tissues using biological tissue substitutes. One approach to achieve this aim is to develop osteoconductive scaffolds that facilitate the formation of functional bone tissue. We have fabricated nanoclay-enriched electrospun poly(É-caprolactone) (PCL) scaffolds for osteogenic differentiation of human mesenchymal stem cells (hMSCs). A range of electrospun scaffolds is fabricated by varying the nanoclay concentrations within the PCL scaffolds. The addition of nanoclay decreases fiber diameter and increases surface roughness of electrospun fibers. The enrichment of PCL scaffold with nanoclay promotes in vitro biomineralization when subjected to simulated body fluid (SBF), indicating bioactive characteristics of the hybrid scaffolds. The degradation rate of PCL increases due to the addition of nanoclay. In addition, a significant increase in crystallization temperature of PCL is also observed due to enhanced surface interactions between PCL and nanoclay. The effect of nanoclay on the mechanical properties of electrospun fibers is also evaluated. The feasibility of using nanoclay-enriched PCL scaffolds for tissue engineering applications is investigated in vitro using hMSCs. The nanoclay-enriched electrospun PCL scaffolds support hMSCs adhesion and proliferation. The addition of nanoclay significantly enhances osteogenic differentiation of hMSCs on the electrospun scaffolds as evident by an increase in alkaline phosphates activity of hMSCs and higher deposition of mineralized extracellular matrix compared to PCL scaffolds. Given its unique bioactive characteristics, nanoclay-enriched PCL fibrous scaffold may be used for musculoskeletal tissue engineering.
File Format	HTM / HTML
ISSN	21524947
e-ISSN	21524955
DOI	10.1089/ten.tea.2013.0281
Journal	Tissue Engineering Part A
Issue Number	15-16
Volume Number	20
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2014-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biotechnology Cell Differentiation Drug Effects Mesenchymal Stromal Cells Cytology Nanoparticles Chemistry Osteogenesis Polyesters Pharmacology Tissue Engineering Tissue Scaffolds Alkaline Phosphatase Metabolism Bone Matrix Physiology Calcification, Physiologic Cell Adhesion Cell Proliferation Mechanical Phenomena Enzymology Nanofibers Temperature Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article

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