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Non-adherent mesenchymal progenitors from adipose tissue stromal vascular fraction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mehrkens, Arne Di Maggio, Nunzia Gueven, Sinan Schaefer, Dirk Scherberich, Arnaud Banfi, Andrea Martin, Ivan
Description	Country affiliation: Switzerland Author Affiliation: Mehrkens A ( Departments of Surgery and of Biomedicine, Basel University Hospital , Basel, Switzerland .)
Abstract	In primary human bone marrow cultures, the initial adherent cell fraction has been shown to provide a microenvironment for self-renewal of primitive non-adherent mesenchymal progenitors (non-adherent progenitors of bone marrow stroma [BM-NAMP]), with increased differentiation potential compared to adherent colony-forming units-fibroblast (CFU-f). The present study investigates whether NAMP exist also in cultures of stromal vascular fraction (SVF) cells derived from human adipose tissue. Adipose-tissue NAMP (AT-NAMP) were shown to be stably non-adherent and their number correlated with the number of the initial adhering CFU-f. Unlike BM-NAMP, AT-NAMP did not propagate in suspension in serial replating experiments and the number of colonies steadily decreased with each replating step. However, when AT-NAMP were kept on the initially adhering SVF cells, they could significantly expand without loss of clonogenic, proliferation, and differentiation potential. Although AT-NAMP progeny differentiated into mesodermal lineages similar to that of adherent CFU-f, it was enriched in early mesenchymal progenitor populations, characterized by increased expression of SSEA-4 and CD146. Furthermore, FGF-2 supported AT-NAMP survival and could not be replaced by another mitogenic factor, such as platelet derived growth factor BB. In conclusion, these data suggest that the SVF adherent fraction provides niche signals that regulate the expansion of adipose non-adherent mesenchymal progenitors with the maintenance of their potency. The biological differences described between BM- and AT-NAMP further qualify the properties of the stroma from different tissues and will be relevant for the selection of a cell source for specific regeneration strategies.
File Format	HTM / HTML
ISSN	21524947
e-ISSN	21524955
DOI	10.1089/ten.TEA.2013.0273
Journal	Tissue Engineering Part A
Issue Number	5-6
Volume Number	20
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biotechnology Adipose Tissue Cytology Mesenchymal Stromal Cells Adipogenesis Cell Adhesion Cell Differentiation Cell Proliferation Cell Survival Cells, Cultured Clone Cells Fibroblast Growth Factor 2 Metabolism Osteogenesis Stromal Cells Subcellular Fractions Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article

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