NDLI: Direct skin involvement of cervical lymph node metastasis from mucosal squamous cell carcinoma of the head and neck.

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Direct skin involvement of cervical lymph node metastasis from mucosal squamous cell carcinoma of the head and neck.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dragan, A. D. Nixon, I. J. Orabi, A. A. Manganaris, A. Jeannon, J-P Guerrero-Urbano, M. T. Simo, R.
Description	Country affiliation: United kingdom Author Affiliation: Dragan AD ( Department of Otorhinolaryngology-Head and Neck Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.); Nixon IJ ( Department of Otorhinolaryngology-Head and Neck Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.); Orabi AA ( Department of Otorhinolaryngology-Head and Neck Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.); Manganaris A ( Department of Otorhinolaryngology-Head and Neck Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.); Jeannon JP ( Department of Otorhinolaryngology-Head and Neck Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.); Guerrero-Urbano MT ( Department of Clinical and Radiation Oncology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.); Simo R ( Department of Otorhinolaryngology-Head and Neck Surgery, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.)
Abstract	INTRODUCTION: Direct skin involvement of nodal metastasis from mucosal head and neck squamous cell carcinoma has traditionally been considered a poor prognostic indicator. METHODS: This retrospective review identified eight patients (five with mucosal upper aerodigestive and three with occult primary squamous cell carcinoma) who presented between 2000 and 2007 with direct skin involvement of nodal metastasis. RESULTS: Five patients were treated with extended radical and three with extended modified radical neck dissection. Closure was achieved directly (four cases), with local (two) or pedicled (two) flaps. Surgery was always followed by radiotherapy (pan-mucosal or to the primary site). The five-year recurrence-free and disease-specific survival rates were 100 per cent. CONCLUSION: It is exceptionally rare to encounter direct skin involvement of metastatic lymph nodes from mucosal head and neck squamous cell carcinoma without evidence of involvement of other anatomical structures. Surgical intervention is possible and combined modality treatment with curative intent is essential, as most patients can have a favourable outcome.
File Format	HTM / HTML
ISSN	00222151
Issue Number	2
Volume Number	127
e-ISSN	17485460
Journal	The Journal of Laryngology & Otology
Language	English
Publisher	Cambridge University Press
Publisher Date	2013-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Otolaryngology Carcinoma, Squamous Cell Pathology Head And Neck Neoplasms Lymph Nodes Mucous Membrane Skin Neoplasms Secondary Aged Aged, 80 And Over Mortality Therapy Disease-free Survival Female Humans Lymphatic Metastasis Male Middle Aged Neoplasm Recurrence, Local Prognosis Retrospective Studies Journal Article
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology

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Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early-stage tongue squamous cell carcinoma.

Direct skin involvement of cervical lymph node metastasis from mucosal squamous cell carcinoma of the head and neck.

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