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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | George, Joe Acharya, Shrikrishna V. Bandgar, Tushar R. Menon, Padma S. Shah, Nalini S. |
| Description | Country affiliation: India Author Affiliation: George J ( Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India.) |
| Abstract | OBJECTIVE: Primary hyperparathyroidism (PHPT) in children and adolescents is a rare condition. Awareness should improve in order to lower threshold for screening and allow intervention before serious and permanent sequelac occur. METHODS: A retrospective analysis of 15 children and adolescents with PHPT (age <20 yr) seen in our clinic between 1993 and 2006. RESULTS: Mean age of patients was 17.73 yr (Range - 13-20, Male-3: Female-12). Average duration of symptoms was 18.87 (range: 0-48) mo. Clinical features at presentation included bone pain (86.67%), proximal myopathy (46.67%), bony deformities (53.33%), fractures (60%), palpable osteitis fibrosa cystica (33.3%), renal calculi (40%), palpable neck swelling (13.3%) and acute pancreatitis (6.67%). None had positive family history or features suggestive of multiple endocrine neoplasia (MEN). After biochemical confirmation, tumor was localised in all prior to surgery. Histopathology confirmed adenoma in all cases. Post-operative hungry bone syndrome occurred in 33.3%. CONCLUSION: PHPT is more common in females. Presentation of the disease is similar to their adult counterparts except for more severe bone disease and less severe renal disease. MEN and familial non-MEN PHPT do not constitute a major cause of pediatric PHPT as against to worldwide data. The incidence of hyperplasia as a cause of PHPT is rare in our pediatric population. |
| File Format | HTM / HTML |
| ISSN | 00195456 |
| Issue Number | 2 |
| Volume Number | 77 |
| e-ISSN | 09737693 |
| Journal | The Indian Journal of Pediatrics |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2010-02-01 |
| Publisher Place | India |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pediatrics Hyperparathyroidism Epidemiology Adolescent Child Comorbidity Female Humans Incidence Male Multiple Endocrine Neoplasia Osteitis Fibrosa Cystica Prevalence Retrospective Studies Young Adult Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
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