NDLI: Clinical significance of and future perspectives for hepatic arterial infusion chemotherapy in patients with liver metastases from colorectal cancer.

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Clinical significance of and future perspectives for hepatic arterial infusion chemotherapy in patients with liver metastases from colorectal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sadahiro, Sotaro Suzuki, Toshiyuki Tanaka, Akira Okada, Kazutake Kamata, Hiroko Koisumi, Jun
Description	Author Affiliation: Sadahiro S ( Department of Surgery, Tokai University, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan, sadahiro@is.icc.u-tokai.ac.jp.)
Abstract	The most common site of metastases in patients with colorectal cancer is the liver. Hepatic resection is considered to be the treatment of choice for liver metastasis from colorectal cancer; however, hepatic resection can be performed in only 20 or 25% of all patients. Recurrence develops in the remnant liver or other organs after hepatic resection in over half of all patients with liver-only metastasis. Hepatic arterial infusion (HAI) chemotherapy can provide relatively high concentrations of drugs to microscopic or macroscopic metastases in the liver, with less toxicity than systemic administration. Meta-analyses have shown HAI chemotherapy to have a significantly higher response rate than systemic chemotherapy and its effect on extrahepatic metastases is negligible. HAI chemotherapy provides much better local control of liver metastases from colorectal cancer than systemic chemotherapy. However, well-controlled studies are needed to elucidate the optimal treatment strategies for neoadjuvant and postoperative adjuvant chemotherapy that optimally combine HAI chemotherapy, molecular targeted agents, and systemic chemotherapy such as FOLFOX or FOLFIRI.
File Format	HTM / HTML
ISSN	09411291
Issue Number	10
Volume Number	43
e-ISSN	14362813
Journal	Surgery Today
Language	English
Publisher	Springer
Publisher Date	2013-10-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Surgery Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Colorectal Neoplasms Pathology Hepatic Artery Infusions, Intra-arterial Methods Trends Liver Neoplasms Drug Therapy Secondary Administration & Dosage Camptothecin Analogs & Derivatives Chemotherapy, Adjuvant Fluorouracil Hepatectomy Humans Leucovorin Prevention & Control Meta-analysis As Topic Neoadjuvant Therapy Neoplasm Staging Organoplatinum Compounds Randomized Controlled Trials As Topic Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Surgery

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R1 resection for aggressive or advanced colorectal liver metastases is justified in combination with effective prehepatectomy chemotherapy.

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Perioperative chemotherapy for resectable hepatic metastases.

Feasibility and short-term outcome of adjuvant FOLFOX after resection of colorectal liver metastases.

Colorectalis májáttétek sebészeti kezelési stratégiájának megválasztása a neoadjuváns kemo- és célzott terápiára adott klinikai és patológiai válasz függvényében.

Exploratory study of hepatic arterial infusion oxaliplatin with systemic 5-fluorouracil/bevacizumab in patients with refractory solid tumor and extensive liver metastases.

Systematic review and meta-analysis of hepatic arterial infusion chemotherapy as bridging therapy for colorectal liver metastases.

Clinical significance of and future perspectives for hepatic arterial infusion chemotherapy in patients with liver metastases from colorectal cancer.

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