NDLI: Expansion of hepatic stem cell compartment boosts liver regeneration.

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Differentiation potential and profile of nuclear receptor expression during expanded culture of human adipose tissue-derived stem cells reveals PPARÎ³ as an important regulator of Oct4 expression.

Detailed expression analysis of regulatory genes in the early developing human neural tube.

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Expansion of hepatic stem cell compartment boosts liver regeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Papp, Veronika Rókusz, András Dezso, Katalin Bugyik, Edina Szabó, Vanessza Pávai, Zoltán Paku, Sándor Nagy, Péter
Description	Country affiliation: Hungary Author Affiliation: Papp V ( 1 First Department of Pathology and Experimental Cancer Research, Semmelweis University , Budapest, Hungary .)
Abstract	The hepatic stem cells reside periportally forming the canals of Hering in normal liver. They can be identified by their unique immunophenotype in rat. The oval cells, the progenies of stem cells invade deep the liver parenchyma after activation and differentiate into focally arranged small-and eventually trabecularly ordered regular hepatocytes. We have observed that upon the completion of intense oval cell reactions narrow ductular structures are present in the parenchyma, we propose to call them parenchymal ductules. These parenchymal ductules have the same immunophenotype [cytokeratin (CK)7-/CK19+/alpha-fetoprotein (AFP)-/delta-like protein (DLK)-] as the resting stem cells of the canals of Hering, but different from them reside scattered in the parenchyma. In our present experiments, we have investigated in an in vivo functional assay if the presence of these parenchymal ductules has any impact on a progenitor cell driven regeneration process. Parenchymal ductules were induced either by an established model of oval cell induction consisting of the administration of necrogenic dose of carbontetrachloride to 2-acetaminofluorene pretreated rats (AAF/CCl4) or a large necrogenic dose of diethylnitrosamine (DEN). The oval cells expanded faster and the foci evolved earlier after repeated injury in the livers with preexistent parenchymal ductules. When the animals were left to survive for one more year increased liver tumor formation was observed exclusively in the DEN treated rats. Thus, repeated oval cell reactions are not necessarily carcinogenic. We conclude that the expansion of hepatic stem cell compartment conceptually can be used to facilitate liver regeneration without an increased risk of tumorigenesis.
File Format	HTM / HTML
ISSN	15473287
e-ISSN	15578534
DOI	10.1089/scd.2013.0202
Journal	Stem Cells and Development
Issue Number	1
Volume Number	23
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cell Biology Discipline Hematology 2-acetylaminofluorene Toxicity Carbon Tetrachloride Liver Regeneration Physiology Stem Cells Metabolism Animals Carbon Tetrachloride Poisoning Cell Differentiation Cell Proliferation Cell Transformation, Neoplastic Drug-induced Liver Injury Diethylnitrosamine Hepatocytes Cytology Liver Liver Neoplasms Chemically Induced Rats, Inbred F344 Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Hematology

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Expansion of Hepatic Stem Cell Compartment Boosts Liver Regeneration

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Expansion of hepatic stem cell compartment boosts liver regeneration.

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Expansion of Hepatic Stem Cell Compartment Boosts Liver Regeneration

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