NDLI: Clinical manifestations, radiographic findings, treatment options, and outcome in sarcoidosis patients with upper respiratory tract involvement.

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Clinical manifestations, radiographic findings, treatment options, and outcome in sarcoidosis patients with upper respiratory tract involvement.

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Clinical manifestations, radiographic findings, treatment options, and outcome in sarcoidosis patients with upper respiratory tract involvement.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Panselinas, Efstratios Halstead, Lucinda Schlosser, Rodney J. Judson, Marc A.
Description	Country affiliation: Greece Author Affiliation: Panselinas E ( 3rd Department of Pulmonary Medicine, Sismanoglion Hospital, Athens, Greece.)
Abstract	BACKGROUND: Sarcoidosis of the upper respiratory tract (SURT) is an underappreciated manifestation of sarcoidosis. We described the clinicoradiological findings, methods of treatment, and outcomes of 68 patients with SURT seen in our clinic over a 7-year period. METHODS: This was a retrospective study. A Case Control Etiology of Sarcoidosis Study (ACCESS) instrument of organ involvement was used to classify patients with SURT. Patients with a definite or probable diagnosis of SURT underwent chart review for symptoms, radiological features, treatment, and outcome. RESULTS: There were 6.8% (68/998) of patients in the sarcoidosis clinic who had SURT. The most common presenting symptom was nasal congestion (61%, 34/56). In patients who had SURT diagnosed after the initial presentation of sarcoidosis, the mean prednisone dose more than quadrupled (4 + or - 6.5 vs 18.6 + or - 15.9, P = 0.002) between the diagnosis of SURT and the end of follow up. By the end of follow up, only 40% of our cohort had significant improvement of SURT. CONCLUSION: SURT is a form of sarcoidosis that is not uncommon. Relatively high doses of corticosteroids are required to control the disease, and improvement occurs in a minority of the patients although the disease usually can be stabilized. Surgery should be reserved for life-threatening complications as surgical outcomes are relatively poor.
File Format	HTM / HTML
ISSN	00384348
Issue Number	9
Volume Number	103
e-ISSN	15418243
Journal	Southern Medical Journal
Language	English
Publisher	Lippincott Williams & Wilkins (for the Southern Medical Association)
Publisher Date	2010-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine Respiratory Tract Diseases Diagnosis Therapy Sarcoidosis Adolescent Adult Aged Female Glucocorticoids Therapeutic Use Hoarseness Etiology Humans Male Middle Aged Nasal Obstruction Prednisone Retrospective Studies Therapeutic Irrigation Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine

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