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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ji, Junfeng Risueño, Ruth M. Hong, Seokho Allan, David Rosten, Patty Humphries, Keith Bhatia, Mickie |
| Description | Country affiliation: Canada Author Affiliation: Ji J ( Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada.) |
| Abstract | Hox genes encode highly conserved transcription factors that have been implicated in hematopoietic development and self-renewal of hematopoietic stem cells (HSCs) and hematopoietic development. The potency of NUP98-HOXA10hd (NA10) on adult murine bone marrow HSC self-renewal prompted us to examine its effect on specification and proliferation of hematopoietic cells derived from human embryonic stem cells (hESCs). Here, we demonstrate that expression of NA10 in hESCs influences the hematopoietic differentiation program. The specific effect of NA10 is dependent on the developmental stage of hematopoietic emergence from hESCs. Overexpression of NA10 in either undifferentiated hESCs or early hemogenic precursors augmented the frequency of CD45(-) GlycophorinA(+) cells and erythroid progenitors (blast-forming unit-erythrocyte). In contrast, targeted NA10 expression in primitive CD34+ cells committed to the hematopoietic lineage had no effect on erythropoietic capacity but instead increased hematopoietic progenitor proliferation. Our study reveals a novel neomorphic effect of NA10 in early human erythroid development from pluripotent stem cells. |
| File Format | HTM / HTML |
| ISSN | 10665099 |
| Issue Number | 4 |
| Volume Number | 29 |
| e-ISSN | 15494918 |
| Journal | STEM CELLS |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2011-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cell Biology Discipline Embryology Cell Differentiation Embryonic Stem Cells Metabolism Erythroid Cells Erythropoiesis Homeodomain Proteins Nuclear Pore Complex Proteins Antigens, Cd34 Antigens, Cd45 Biosynthesis Cell Proliferation Cells, Cultured Cytology Flow Cytometry Gene Expression Glycophorin Genetics Humans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Medicine |
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