NDLI: Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration.

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Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fukuda, Shinichi Nagano, Masumi Yamashita, Toshiharu Kimura, Kenichi Tsuboi, Ikki Salazar, Georgina Ueno, Shinji Kondo, Mineo Kunath, Tilo Oshika, Tetsuro Ohneda, Osamu
Description	Country affiliation: Japan Author Affiliation: Fukuda S ( Department of Regenerative Medicine and Stem Cell Biology, Graduate School of Comprehensive Human Science)
Abstract	Retinitis pigmentosa is a group of inherited eye disorders that result in profound vision loss with characteristic retinal neuronal degeneration and vasculature attenuation. In a mouse model of retinitis pigmentosa, endothelial progenitor cells (EPC) from bone marrow rescued the vasculature and photoreceptors. However, the mechanisms and cell types underlying these protective effects were uncertain. We divided EPC, which contribute to angiogenesis, into two subpopulations based on their aldehyde dehydrogenase (ALDH) activity and observed that EPC with low ALDH activity (Alde-Low) had greater neuroprotection and vasoprotection capabilities after injection into the eyes of an rd1 mouse model of retinitis pigmentosa compared with EPC with high ALDH activity (Alde-High). Of note, Alde-Low EPC selectively recruited F4/80(+) /Ly6c(+) monocyte-derived macrophages from bone marrow into retina through CCL2 secretion. In addition, the mRNA levels of CCR2, the neurotrophic factors TGF-ß1 and IGF-1, and the anti-inflammatory mediator interleukin-10 were higher in migrated F4/80(+) /Ly6c(+) monocyte-derived macrophages as compared with F4/80(+) /Ly6c(-) resident retinal microglial cells. These results suggest a novel therapeutic approach using EPC to recruit neuroprotective macrophages that delay the progression of neural degenerative disease.
File Format	HTM / HTML
ISSN	10665099
Issue Number	10
Volume Number	31
e-ISSN	15494918
Journal	STEM CELLS
Language	English
Publisher	Wiley
Publisher Date	2013-10-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Embryology Antigens, Differentiation Metabolism Antigens, Ly Macrophages Physiology Retinitis Pigmentosa Therapy Stem Cell Transplantation Animals Bone Marrow Cells Cells, Cultured Chemokines Genetics Chemotaxis Endothelial Cells Gene Expression Human Umbilical Vein Endothelial Cells Insulin-like Growth Factor I Transplantation Mice Mice, Inbred C3h Mice, Inbred C57bl Microglia Nerve Degeneration Prevention & Control Retina Pathology Retinal Neurons Retinal Vessels Physiopathology Immunology Stem Cells Transforming Growth Factor Beta1 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Medicine Molecular Medicine

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Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration.

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Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration.