NDLI: Natural history of COPD: Focusing on change in FEV1.

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Natural history of COPD: Focusing on change in FEV1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vestbo, Jørgen Lange, Peter
Description	Country affiliation: United kingdom Author Affiliation: Vestbo J ( Centre for Respiratory Medicine and Allergy, Manchester Academic Health Science Centre, University Hospital South Manchester, NHS Foundation Trust, Manchester, UK.); Lange P ( Department of Social Medicine, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark.)
Abstract	The natural history of chronic obstructive pulmonary disease (COPD) is usually described with a focus on change in forced expiratory volume in 1 s (FEV1 ) over time as this allows for exploration of risk factors for an accelerated decline-and thus of developing COPD. From epidemiological studies we have recognized important risk factors such as smoking, exposure to biomass and occupational exposures, but we have also learnt about features such as chronic bronchitis, airway hyper-responsiveness and asthma that seem to accelerate decline in FEV1 independent of exposures. In addition we are gradually beginning to better link early life events to subsequent risk of disease in adulthood. Although more complicated, our current understanding of COPD has come a long way from being a simple image of smoking leading to poor lungs.
File Format	HTM / HTML
ISSN	13237799
Issue Number	1
Volume Number	21
e-ISSN	14401843
Journal	Respirology
Language	English
Publisher	Wiley
Publisher Date	2016-01-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pulmonary Medicine Forced Expiratory Volume Occupational Exposure Adverse Effects Pulmonary Disease, Chronic Obstructive Etiology Physiopathology Smoking Asthma Biomass Bronchitis, Chronic Diet Humans Risk Factors Social Class Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine

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Natural history of COPD: Focusing on change in FEV1.

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