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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Menezes, Marcelo B. Teixeira, Antônio L. Terra Filho, João Vianna, Elcio O. |
| Description | Country affiliation: Brazil Author Affiliation: Menezes MB ( Department of Medicine, University of S. Paulo Medical School at Ribeirão Preto, Brazil.) |
| Abstract | Adding a long-acting beta(2)-agonist to inhaled corticosteroids (ICS) for asthma treatment is better than increasing ICS dose in improving clinical status, although there is no consensus about the impact of this regimen on inflammation. In this double-blind, randomized, parallel group study, asthmatics with moderate to severe disease used budesonide (400 mcg/day) for 5 weeks (run-in period); then they were randomized to use budesonide (800 mcg/day--BUD group) or budesonide plus formoterol (400 mcg and 24 mcg/day, respectively--FORMO group) for 9 weeks (treatment period). Home PEF measurements, symptom daily reporting, spirometry, sputum induction (for differential cell counts and sputum cell cultures), and hypertonic saline bronchial challenge test were performed before and after treatments. TNF-alpha, IL-4 and eotaxin-2 levels in the sputum and cell culture supernatants were determined. Morning and night PEF values increased in the FORMO group during the treatment period (p<0.01), from 435+/-162 to 489+/-169 and 428+/-160 to 496+/-173 L/min, respectively. The rate of exacerbations in the FORMO group was lower than in the BUD group (p<0.05). Neutrophil counts in sputum increased in both groups (p<0.05) and leukocyte viability after 48 h-culture increased in the FORMO group (p<0.05). No other parameter changed significantly in either group. This study showed that adding formoterol to budesonide improved home PEF and provided protection from exacerbations, although increase of leukocyte viability in cell culture may be a matter of concern and needs further investigation. |
| File Format | HTM / HTML |
| ISSN | 09546111 |
| Issue Number | 10 |
| Volume Number | 102 |
| e-ISSN | 15323064 |
| Journal | Respiratory Medicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonary Medicine Asthma Drug Therapy Bronchodilator Agents Administration & Dosage Budesonide Ethanolamines Administration, Inhalation Adrenergic Beta-agonists Therapeutic Use Adult Immunology Physiopathology Cytokines Double-blind Method Drug Administration Schedule Drug Therapy, Combination Female Formoterol Fumarate Glucocorticoids Humans Lung Male Middle Aged Peak Expiratory Flow Rate Treatment Failure Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
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