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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Antus, Balazs Horvath, Ildiko Barta, Imre |
| Description | Country affiliation: Hungary Author Affiliation: Antus B ( Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary. antusb@hotmail.com) |
| Abstract | BACKGROUND: Fractional exhaled nitric oxide (FENO) has been implicated as a pulmonary biomarker. The aim of this study was to compare the performance of a new hand-held device to a standard chemiluminescence analyzer and to another portable device. METHODS: FENO levels measured by NObreath (Bedfont) were compared to those of (1) a chemiluminescence detector (Logan, Logan Research) and (2) the electrochemical portable NIOX MINO (Aerocrine) in 18 healthy volunteers on three consecutive occasions: in the morning, 1 h and 24 h later. RESULTS: Comparing FENO levels obtained by NObreath to those by Logan values were similar and a very close linear relationship was found between the two devices (r = 0.923, p < 0.001). The mean inter-device difference in FENO level was -3.45 ppb and the limits of agreement (Bland-Altman test) were -10.98 and 4.08 ppb. In the second series FENO levels obtained by NObreath were found to be slightly higher compared to those of NIOX MINO, but still showed a close correlation (r = 0.681, p < 0.001). The mean inter-device difference in FENO level was 4.36 ppb and the limits of agreement were -7.38 and 16.1 ppb. Analyzing the repeated FENO measurements, the mean coefficient of variation using NObreath tended to be lower than that of NIOX MINO (16.9 vs. 24.7%, p = 0.059), while it was similar as the value obtained with Logan (11.8 vs. 9.0%, p = 0.342). CONCLUSIONS: FENO values measured with NObreath are reproducible and in good agreement with those obtained by NIOX MINO and Logan indicating that NObreath is suitable for use in clinical practice. |
| File Format | HTM / HTML |
| ISSN | 09546111 |
| Issue Number | 9 |
| Volume Number | 104 |
| e-ISSN | 15323064 |
| Journal | Respiratory Medicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonary Medicine Breath Tests Instrumentation Nitric Oxide Analysis Biological Markers Computers, Handheld Equipment Design Exhalation Female Humans Male Middle Aged Reproducibility Of Results Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
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