NDLI: Immunological changes induced by Toxoplasma gondii Glutathione-S-Transferase (TgGST) delivered as a DNA vaccine.

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Immunological changes induced by Toxoplasma gondii Glutathione-S-Transferase (TgGST) delivered as a DNA vaccine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Shuai Hassan, Ibrahim A. Liu, XinChao Xu, LiXin Yan, RuoFeng Song, XiaoKai Li, XiangRui
Description	Country affiliation: China Author Affiliation: Wang S ( Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.); Hassan IA ( Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.); Liu X ( Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.); Xu L ( Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.); Yan R ( Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.); Song X ( Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.); Li X ( Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China. Electronic address: lixiangrui@njau.edu.cn.)
Abstract	In this study, a DNA vaccine (pTgGST) encoding T. gondii antioxidant glutathione-S-transferase (TgGST) inserted into eukaryotic expression vector pVAX I was constructed and the immune protective efficacy of intramuscular vaccination of mice with pTgGST was analyzed. Mice immunized with pTgGST elicited high titers of total IgG, IgG1, IgG2a, IgA and IgM antibodies, while IgE showed no changes. Also, significant cytokine production of IFN-Î³, IL-4 and IL-17 was detected in mice immunized with pTgGST, but not TGF-ß1. CD8(+) T cells subsets and MHC-I molecules showed significant increase in contrast to CD4(+) subsets. Immunization with pTgGST significantly prolonged survival time (14 days) after challenge infection with the virulent T. gondii RH strain, compared with the control groups which died within 8 days. These results suggested that TgGST DNA vaccine could trigger strong humoral and cellular responses and induce partial protection against acute toxoplasmosis.
File Format	HTM / HTML
ISSN	00345288
Volume Number	99
e-ISSN	15322661
Journal	Research in Veterinary Science
Language	English
Publisher	Elsevier
Publisher Date	2015-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Veterinary Medicine Glutathione Transferase Immunology Protozoan Proteins Protozoan Vaccines Toxoplasma Toxoplasmosis, Animal Animals Female Mice Parasitology Vaccines, Dna Pharmacology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Veterinary

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