NDLI: Implication of FKBP6 for Male Fertility in Horses

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Implication of FKBP6 for Male Fertility in Horses

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Implication of FKBP6 for Male Fertility in Horses

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schrimpf, R. Metzger, J. Martinsson, G. Sieme, H. Distl, O.
Description	Country affiliation: Germany Author Affiliation: Schrimpf R ( Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany.)
Abstract	In stallions, impaired acrosome reaction (IAR) may often cause subfertility. Single nucleotide polymorphisms (SNPs) within FK506-binding protein (FKBP6) seem to be associated with IAR in stallions. However, their effect on stallion fertility has not yet been quantified. Using whole-genome sequence data of seven stallions, we searched FKBP6 for mutations to perform an association study in Hanoverian stallions with estimated breeding values for the paternal component of the pregnancy rate per oestrus cycle (EBV-PAT) as target trait. Genotyping five exonic mutations within FKBP6 revealed a significant association of the SNP g.11040379C>A (p.167H>N) with EBV-PAT in 216 Hanoverian stallions. The difference among the two homozygous genotypes was 7.62% in EBV-PAT, corresponding to one standard deviation of EBV-PAT. In conclusion, in Hanoverian stallions, the FKBP6-associated SNP g.11040379C>A confers higher conception rates in A/A homozygous and lower conception rates in C/C homozygous Hanoverian stallions. Thus, an FKBP6-associated missense mutation is significantly associated with stallion fertility.
File Format	HTM / HTML
ISSN	09366768
Issue Number	2
Volume Number	50
e-ISSN	14390531
Journal	Reproduction in Domestic Animals
Language	English
Publisher	Wiley
Publisher Date	2015-04-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Reproductive Medicine Discipline Veterinary Medicine Discipline Zoology Fertility Genetics Horses Physiology Immunophilins Metabolism Tacrolimus Binding Proteins Animals Female Gene Expression Regulation Genotype Haplotypes Male Mutation Polymorphism, Single Nucleotide Pregnancy Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology Endocrinology Biotechnology

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