| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Woo, Hyun Park, Se Jin Lee, Younghwa Kwon, Guyoung Gao, Qingtao Lee, Hyung Eun Ahn, Young Je Shin, Chan Young Cheong, Jae Hoon Ryu, Jong Hoon |
| Description |
Author Affiliation: Woo H ( Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea); Park SJ ( Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea); Lee Y ( Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea); Kwon G ( Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea); Gao Q ( Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea); Lee HE ( Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea); Ahn YJ ( Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea); Shin CY ( Department of Neuroscience, School of Medicine and Neuroscience Research Center, Institute SMART-IABS, Konkuk University, Seoul 143-701, Republic of Korea.); Cheong JH ( Department of Pharmacy, Uimyung Research Institute for Neuroscience, Sahmyook University, Seoul 139-742, Republic of Korea.); Ryu JH ( Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea) |
| Abstract |
Atomoxetine (ATM) and methylphenidate (MPD) have been used for the treatment of attention deficit hyperactivity disorder (ADHD). ATM is a selective norepinephrine reuptake inhibitor, whereas MPD is a psychostimulant and acts as a norepinephrine and dopamine reuptake inhibitor. In the present study, we investigated the effects of ATM (1, 3 or 10mg/kg) and MPD (5, 10 or 20mg/kg) on pharmacological mouse models of sensorimotor gating measured by prepulse inhibition (PPI) using the acoustic startle response test. MK-801, a non-competitive N-methyl-d-aspartate receptor antagonist, or apomorphine, a non-competitive dopamine receptor agonist, was used to induce PPI deficits. ATM (3 or 10mg/kg, s.c.) significantly attenuated the MK-801-, but not apomorphine-, induced PPI deficits. In contrast to ATM, MPD did not reverse the PPI deficits induced by either MK-801 or apomorphine. Immunostaining revealed that the number of c-Fos-immunopositive cells was increased in the nucleus accumbens following MK-801 treatment, and this was reversed by the administration of ATM (3mg/kg), but not MPD (10mg/kg). However, neither ATM nor MPD reversed the increased number of c-Fos-immunopositive cells in the nucleus accumbens following apomorphine treatment. These results suggest that the attenuating effect of ATM on the increased c-Fos immunoreactivity in the nucleus accumbens induced by MK-801 may be attributed to the PPI deficit-ameliorating effects of ATM and that ATM would be useful to treat sensorimotor gating-related disorders by improving the patient's attention span or cognitive function. |
| File Format |
HTM / HTML |
| ISSN |
02785846 |
| Volume Number |
54 |
| e-ISSN |
18784216 |
| Journal |
Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-10-03 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Psychiatry Adrenergic Uptake Inhibitors Pharmacology Dopamine Uptake Inhibitors Methylphenidate Prepulse Inhibition Drug Effects Propylamines Sensory Gating Acoustic Stimulation Animals Apomorphine Atomoxetine Hydrochloride Auditory Perception Physiology Dizocilpine Maleate Dopamine Agonists Dose-response Relationship, Drug Excitatory Amino Acid Antagonists Male Mice, Inbred Icr Nucleus Accumbens Physiopathology Proto-oncogene Proteins C-fos Metabolism Reflex, Startle Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Biological Psychiatry Pharmacology |
