| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Wakuda, Tomoyasu Iwata, Keiko Iwata, Yasuhide Anitha, Ayyappan Takahashi, Taro Yamada, Kohei Vasu, Mahesh Mundalil Matsuzaki, Hideo Suzuki, Katsuaki Mori, Norio |
| Description |
Country affiliation: Japan Author Affiliation: Wakuda T ( Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.); Iwata K ( Research Center for Child Mental Development, University of Fukui, Eiheiji-cho, Japan.); Iwata Y ( Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.); Anitha A ( Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.); Takahashi T ( Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.); Yamada K ( Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.); Vasu MM ( Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.); Matsuzaki H ( Research Center for Child Mental Development, University of Fukui, Eiheiji-cho, Japan.); Suzuki K ( Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. Electronic address: k-suzuki@hama-med.ac.jp.); Mori N ( Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan) |
| Abstract |
Epidemiological studies suggest that perinatal complications, particularly hypoxia-related ones, increase the risk of schizophrenia. Recent genetic studies of the disorder have identified several putative susceptibility genes, some of which are known to be regulated by hypoxia. It can be postulated therefore that birth complications that cause hypoxia in the fetal brain may be associated with a dysregulation in the expression of some of the schizophrenia candidate genes. To test this, we used an animal model of perinatal asphyxia, in which rat pups were exposed to 15 min of intrauterine anoxia during Caesarean section birth, and examined the expression of mRNA of five of the putative susceptibility genes (NRG1, ErbB4, AKT1, COMT and BDNF) by real-time quantitative PCR in the medial prefrontal cortex (mPFC) and the hippocampus at 6 and 12 weeks after birth. The expression of NRG1 mRNA was significantly decreased in the mPFC, but not in the hippocampus, at 6 and 12 weeks after birth. In addition, a significant increase in COMT mRNA expression was observed in the mPFC at 12 weeks. The alteration in mRNA levels of NRG1 and COMT was not associated with a change in their protein levels. These results suggest that perinatal asphyxia may lead to disturbances in the PFC, which in turn may exert a long-lasting influence on the expression of specific genes, such as NRG1 and COMT. Our results also suggest that translational interruption may occur in this model of perinatal asphyxia. |
| File Format |
HTM / HTML |
| ISSN |
02785846 |
| Volume Number |
56 |
| e-ISSN |
18784216 |
| Journal |
Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2015-01-02 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Psychiatry Asphyxia Pathology Catechol O-methyltransferase Metabolism Gene Expression Regulation Physiology Neuregulin-1 Prefrontal Cortex Age Factors Analysis Of Variance Animals Genetics Female Male Pregnancy Rna, Messenger Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Biological Psychiatry Pharmacology |
